Peramivir Trihydrate (RWJ-270201) is a neuraminidase inhibitor (IC50: 0.09 nM) which prevents normal processing of virus particles such that virus particles are not released from infected cells. Peramivir Trihydrate is a cyclopentane derivative with activity against influenza A and B viruses.

Neuraminidase:0.09 nM

When used in conjunction with favipiravir (20-40 mg/kg/day), peramivir (0.025-0.1 mg/kg/day) increases cell survival rates by 10-50%. At a dosage of 0.5 mg/kg/day, peramivir exhibits a protective effect against H1N1 in mice, covering about 30% of the virus. The combination of peramivir (1 mg/kg/day) with amantadine (5-10 mg/kg/day) results in weight losses of 1.69 and 0.69, respectively; however, for a sub-lethal influenza A (H3N2) virus model in mice, administering peramivir (3 mg/kg/day) alongside rimantadine (10-30 mg/kg/day) does not affect weight. At a higher concentration, peramivir (30 mg/kg) effectively extends the survival of mice infected with the systemically replicating H5N1 virus.