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Peramivir Trihydrate
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Peramivir Trihydrate
Catalog No. T2522Cas No. 1041434-82-5
Peramivir Trihydrate (RWJ-270201) is a neuraminidase inhibitor (IC50: 0.09 nM) which prevents normal processing of virus particles such that virus particles are not released from infected cells. Peramivir Trihydrate is a cyclopentane derivative with activity against influenza A and B viruses.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $39 | In Stock | |
| 5 mg | $64 | In Stock | |
| 10 mg | $105 | In Stock | |
| 25 mg | $198 | In Stock | |
| 50 mg | $328 | In Stock | |
| 100 mg | $463 | In Stock | |
| 200 mg | $668 | In Stock | |
| 500 mg | $987 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Peramivir Trihydrate (RWJ-270201) is a neuraminidase inhibitor (IC50: 0.09 nM) which prevents normal processing of virus particles such that virus particles are not released from infected cells. Peramivir Trihydrate is a cyclopentane derivative with activity against influenza A and B viruses. |
| In vitro | When used in conjunction with favipiravir (20-40 mg/kg/day), peramivir (0.025-0.1 mg/kg/day) increases cell survival rates by 10-50%. At a dosage of 0.5 mg/kg/day, peramivir exhibits a protective effect against H1N1 in mice, covering about 30% of the virus. The combination of peramivir (1 mg/kg/day) with amantadine (5-10 mg/kg/day) results in weight losses of 1.69 and 0.69, respectively; however, for a sub-lethal influenza A (H3N2) virus model in mice, administering peramivir (3 mg/kg/day) alongside rimantadine (10-30 mg/kg/day) does not affect weight. At a higher concentration, peramivir (30 mg/kg) effectively extends the survival of mice infected with the systemically replicating H5N1 virus. |
| Alias | RWJ-270201, S-021812, BCX-1812, RWJ 270201 trihydrate, BCX 1812 trihydrate |
| Molecular Weight | 382.45 |
| Formula | C15H28N4O4·3H2O |
| Cas No. | 1041434-82-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||
| Solubility Information | H2O: 6.6 mg/mL (17.26 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
H2O
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