Shopping Cart
- Remove All
Your shopping cart is currently empty
PHTPP
🥰Excellent
Catalog No. T4388Cas No. 805239-56-9
PHTPP is a selective ERβ antagonist.
PHTPP
🥰Excellent
Purity: 99.72%
Catalog No. T4388Cas No. 805239-56-9
PHTPP is a selective ERβ antagonist.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $30 | In Stock | |
| 5 mg | $48 | In Stock | |
| 10 mg | $78 | In Stock | |
| 25 mg | $157 | In Stock | |
| 50 mg | $253 | In Stock | |
| 100 mg | $397 | In Stock | |
| 500 mg | $928 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "PHTPP"
Kaempferol
Cited
Robigenin, Kempferol
T2177520-18-3
Kaempferol (Robigenin) is a natural flavonoid and an inverse agonist of ERRα and ERRγ. Kaempferol has a wide range of antitumor, anti-inflammatory, antioxidant, antibacterial and antiviral activities.
ApoptosisAutophagyEndogenous MetaboliteEstrogen Receptor/ERREstrogen/progestogen ReceptorHIV ProteaseMitophagyParasite
- $46
Size
QTY
CitedEthisterone
Pregneninolone, 17α-Ethynyltestosterone
T0301434-03-7
Ethisterone (17α-Ethynyltestosterone) is a progestogen hormone.
- $50
Size
QTY
Melatonin Cited
N-Acetyl-5-methoxytryptamine, Melatonine
T165973-31-4
Melatonin (Melatonine) is a natural hormone secreted by the pineal gland that activates melatonin receptors. Melatonin is a hormone that regulates the biological clock and also has antioxidant and anti-inflammatory activities.
ApoptosisAutophagyCaMKEndogenous MetaboliteEstrogen/progestogen ReceptorGlutathione PeroxidaseMelatonin ReceptorMitophagyROR
- $31
Size
QTY
CitedMifepristone
RU486, RU 38486, C-1073
T110284371-65-3
Mifepristone (C-1073) is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
- $37
Size
QTY
Tamoxifen
Cited
Z-Tamoxifen, trans-Tamoxifen, ICI47699
T690610540-29-1
Tamoxifen (ICI47699) is a selective and orally effective estrogen receptor modulator (SERM). Tamoxifen has both inhibitory (e.g., mammary cells) and activating (e.g., bone, liver, and uterine cells) activity against estrogens.
- $39
Size
QTY
CitedEstradiol Cited
β-Estradiol, E2, 17β-Oestradiol, 17β-Estradiol
T104850-28-2
Estradiol (E2) is a naturally occurring steroidal sex hormone that is essential for female fertility and maintenance of secondary sexual characteristics. Estradiol upregulates IL-6 expression through estrogen receptor beta (ERβ).
- $28
Size
QTY
CitedCholesterol Cited
Cholesteryl alcohol, Cholesterin
T076057-88-5
Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is widely found in the cell membranes of animals and is also used in the synthesis of several important hormones and bile acids.
- $45
Size
QTY
CitedAstragaloside IV Cited
AST-IV, AS-IV
T297384687-43-4
Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells. Astragaloside IV is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine.1 It dose-dependently inhibits human adenovirus type 3 (HAdV-3) in A549 cells (IC50 = 23 μM; LC50 = 865 μM).It inhibits replication of HAdV-3 and decreases HAdV-3-induced apoptosis. It has diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. In particular, it reduces myocardial infarct size in dogs when administered prior to coronary ligation and reduces reperfusion arrhythmias in isolated rat hearts.
- $32
Size
QTY
CitedEstradiol benzoate Cited
Benzoestrofol, Benzhormovarine, Benovocylin
T038450-50-0
Estradiol benzoate (Benzhormovarine) is the synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females.
- $45
Size
QTY
CitedChrysin Cited
NSC 407436, 5,7-Dihydroxyflavone, 5, 7-Dihydroxyflavone
T2837480-40-0
Chrysin (5,7-Dihydroxyflavone) exhibits many biological activities and pharmacological effects, including antioxidant, anti-inflammatory, anticancer, and antiviral activities.
- $42
Size
QTY
CitedAllura Red AC
FD&C RED NO. 40, CI 16035, Allura Red
TN137025956-17-6
Allura Red AC (CI 16035) is a very important food azo dye used in the food, pharmaceutical, paper, cosmetic and textile industries.Allura Red AC promotes susceptibility to experimental colitis via mouse intestinal serotonin.
- $50
Size
QTY
Natamycin Cited
Pimaricin
T07097681-93-8
Natamycin (Pimaricin) is a Polyene Antimicrobial.
- $38
Size
QTY
CitedSelect Batch
Purity:99.72%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PHTPP is a selective ERβ antagonist. |
| In vitro | PHTPP acts as a selective antagonist for estrogen receptor beta (ERβ), significantly decreasing follicle-stimulating hormone (FSH)-mediated cyclic AMP (cAMP) production by 80% (p<0.01), without impacting basal cAMP levels. At a concentration of 10^-6 M, PHTPP inhibits estradiol (E2)-stimulated ERβ activity but does not affect E2-induced ERα activity. Furthermore, a high concentration of PHTPP (10^-6 M) marginally enhances class 1 Igf1 mRNA expression and promotes the DPN-induced increase in class 1 Igf1 mRNA expression. |
| Cell Research | Cells are plated at a density of 3 to 4×10^5 in 1 mL of medium per well in a 24-well plate for cell viability and cAMP analysis. Cells are cultured in Dulbecco's Modified Eagle Medium with PHTPP (1 μM), or ethanol (0.1%) as the vehicle. The incubator is set to an atmosphere of 5% CO2 in air at 37°C, and cultures are allowed to acclimate for at least 24 h. The culture medium is then aspirated and replaced with serum-free DMEM/F12 containing 0.1 μM androstenedione. The cells are collected for intracellular cAMP and to test cell viability. They are for reference only. |
| Molecular Weight | 423.31 |
| Formula | C20H11F6N3O |
| Cas No. | 805239-56-9 |
| Smiles | Oc1ccc(cc1)-c1c(nn2c(cc(nc12)C(F)(F)F)C(F)(F)F)-c1ccccc1 |
| Relative Density. | 1.48g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 21.67 mg/mL (51.18 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy PHTPP | purchase PHTPP | PHTPP cost | order PHTPP | PHTPP chemical structure | PHTPP in vitro | PHTPP formula | PHTPP molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.