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Pozanicline dihydrochloride

Pozanicline dihydrochloride
Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable agonist of the nicotinic acetylcholine receptor (nAChR) with a Ki of 16.7 nM.
Catalog No. T12525Cas No. 161416-61-1

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Pozanicline dihydrochloride

Catalog No. T12525Alias ABT-089 dihydrochlorideCas No. 161416-61-1

Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable agonist of the nicotinic acetylcholine receptor (nAChR) with a Ki of 16.7 nM.
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Product Introduction

Bioactivity
Description
Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable agonist of the nicotinic acetylcholine receptor (nAChR) with a Ki of 16.7 nM.
Targets&IC50
α6β2 nAChR:0.11 μM(EC50), α4β2 nAChR:17 nM(Ki,rat brain), nAChR:16.7 nM(Ki)
In vitro
Pozanicline is a partial agonist at α4β2 nAChR. Moreover, one α6β2 nAChR subtype is particularly sensitive to Pozanicline (EC50 of 0.11 μM)[2]. Pozanicline shows high selectivity for α6β2 and α4α5β2 nAChR subtypes[3].
In vivo
ABT-089, a partial agonist of α4β2*, and ABT-107, an α7 nicotinic acetylcholine receptor agonist, for amelioration of cognitive deficits induced by withdrawal from chronic nicotine in mice.?Mice underwent chronic nicotine administration (12.6 mg/kg/day or saline for 12 days), followed by 24 h of withdrawal.?At the end of withdrawal, mice received 0.3 or 0.6 mg/kg ABT-089 or 0.3 mg/kg ABT-107 (doses were determined through initial dose-response experiments and prior studies) and were trained and tested for CFC.?Nicotine withdrawal produced deficits in CFC that were reversed by acute ABT-089, but not ABT-107.?Cued conditioning was not affected.?modulation of hippocampal learning and memory using ABT-089 may be an effective component of novel therapeutic strategies for nicotine addiction[3].
AliasABT-089 dihydrochloride
Chemical Properties
Molecular Weight265.18
FormulaC11H18Cl2N2O
Cas No.161416-61-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 100 mg/mL (377.10 mM)
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM3.7710 mL18.8551 mL37.7102 mL188.5512 mL
5 mM0.7542 mL3.7710 mL7.5420 mL37.7102 mL
10 mM0.3771 mL1.8855 mL3.7710 mL18.8551 mL
20 mM0.1886 mL0.9428 mL1.8855 mL9.4276 mL
50 mM0.0754 mL0.3771 mL0.7542 mL3.7710 mL
100 mM0.0377 mL0.1886 mL0.3771 mL1.8855 mL

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