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Pozanicline dihydrochloride

Name: Pozanicline dihydrochloride
Brand: TargetMol
SKU: T12525
Rating: 4.5 (1 reviews)

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Catalog No. T12525Cas No. 161416-61-1

Alias ABT-089 dihydrochloride

Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable agonist of the nicotinic acetylcholine receptor (nAChR) with a Ki of 16.7 nM.

Pozanicline dihydrochloride

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Catalog No. T12525Alias ABT-089 dihydrochlorideCas No. 161416-61-1

Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable agonist of the nicotinic acetylcholine receptor (nAChR) with a Ki of 16.7 nM.

Pack Size	Price	Availability	Quantity
2 mg	$79	5 days

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Product Introduction

Bioactivity

Description	Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable agonist of the nicotinic acetylcholine receptor (nAChR) with a Ki of 16.7 nM.
Targets&IC50	α4β2 nAChR:17 nM(Ki,rat brain), nAChR:16.7 nM(Ki), α6β2 nAChR:0.11 μM(EC50)
In vitro	Pozanicline is a partial agonist at α4β2 nAChR. Moreover, one α6β2 nAChR subtype is particularly sensitive to Pozanicline (EC50 of 0.11 μM)[2]. Pozanicline shows high selectivity for α6β2 and α4α5β2 nAChR subtypes[3].
In vivo	ABT-089, a partial agonist of α4β2*, and ABT-107, an α7 nicotinic acetylcholine receptor agonist, for amelioration of cognitive deficits induced by withdrawal from chronic nicotine in mice.?Mice underwent chronic nicotine administration (12.6 mg/kg/day or saline for 12 days), followed by 24 h of withdrawal.?At the end of withdrawal, mice received 0.3 or 0.6 mg/kg ABT-089 or 0.3 mg/kg ABT-107 (doses were determined through initial dose-response experiments and prior studies) and were trained and tested for CFC.?Nicotine withdrawal produced deficits in CFC that were reversed by acute ABT-089, but not ABT-107.?Cued conditioning was not affected.?modulation of hippocampal learning and memory using ABT-089 may be an effective component of novel therapeutic strategies for nicotine addiction[3].
Alias	ABT-089 dihydrochloride

Chemical Properties

Molecular Weight	265.18
Formula	C₁₁H₁₈Cl₂N₂O
Cas No.	161416-61-1
Smiles	Cl.Cl.Cc1ncccc1OC[C@@H]1CCCN1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 100 mg/mL (377.10 mM)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.7710 mL	18.8551 mL	37.7102 mL	188.5512 mL
5 mM	0.7542 mL	3.7710 mL	7.5420 mL	37.7102 mL
10 mM	0.3771 mL	1.8855 mL	3.7710 mL	18.8551 mL
20 mM	0.1886 mL	0.9428 mL	1.8855 mL	9.4276 mL
50 mM	0.0754 mL	0.3771 mL	0.7542 mL	3.7710 mL
100 mM	0.0377 mL	0.1886 mL	0.3771 mL	1.8855 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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