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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $117 | In Stock | |
5 mg | $262 | In Stock | |
10 mg | $387 | In Stock | |
25 mg | $592 | In Stock | |
50 mg | $828 | In Stock | |
100 mg | $1,110 | In Stock | |
500 mg | $2,230 | In Stock | |
1 mL x 10 mM (in DMSO) | $227 | In Stock |
Description | Pozanicline hydrochloride is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a Ki of 16.7 nM for binding to [3H]cytisine sites[1]. Pozanicline hydrochloride is an α4β2-selective nAChR agonist, which binds to rat brain α4β2 nAChR with a Ki of 17 nM while binding to α7 nAChR is insignificant[2]. |
In vitro | Pozanicline hydrochloride is a partial agonist at α4β2 nAChR. Moreover, one α6β2 nAChR subtype is particularly sensitive to Pozanicline with an EC50 of 0.11 μM[2]. Pozanicline hydrochloride shows high selectivity for α6β2 and α4α5β2 nAChR subtypes[3]. |
In vivo | Pozanicline hydrochloride (0.3 mg/kg and 0.6 mg/kg) reverses nicotine withdrawal-induced deficits in contextual fear conditioning[3]. |
Molecular Weight | 228.72 |
Formula | C11H17ClN2O |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 55 mg/mL (240.47 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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