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PQCA
🥰Excellent
Catalog No. T12531Cas No. 1144504-35-7
PQCA is a muscarinic M1 receptor-positive allosteric regulator, which is highly selective and effective. PQCA exhibited EC50 values of 49 nM in rhesus monkey and 135 nM in human M1 receptors, but showed no activity against other muscarinic receptors. PQCA is a potential compound for reducing cognitive deficits associated with Alzheimer's disease.
PQCA
🥰Excellent
Purity: 98.95%
Catalog No. T12531Cas No. 1144504-35-7
PQCA is a muscarinic M1 receptor-positive allosteric regulator, which is highly selective and effective. PQCA exhibited EC50 values of 49 nM in rhesus monkey and 135 nM in human M1 receptors, but showed no activity against other muscarinic receptors. PQCA is a potential compound for reducing cognitive deficits associated with Alzheimer's disease.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $47 | In Stock | |
| 5 mg | $118 | In Stock | |
| 10 mg | $202 | In Stock | |
| 25 mg | $320 | In Stock | |
| 50 mg | $443 | In Stock | |
| 100 mg | $589 | In Stock |
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Purity:98.95%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PQCA is a muscarinic M1 receptor-positive allosteric regulator, which is highly selective and effective. PQCA exhibited EC50 values of 49 nM in rhesus monkey and 135 nM in human M1 receptors, but showed no activity against other muscarinic receptors. PQCA is a potential compound for reducing cognitive deficits associated with Alzheimer's disease. |
| Targets&IC50 | M1 receptor (human):135 nM (EC50), M1 receptor (human):135 nM (EC50), M1 receptor (rhesus):49 nM (EC50), M1 receptor (rhesus):49 nM (EC50) |
| In vivo | In male rhesus monkeys, oral administration of PQCA (3-30 mg/kg) effectively mitigates the cognitive impairments induced by scopolamine in both the paired-associates learning (PAL) and the continuous performance task (CPT). Scopolamine-induced blockade of muscarinic signaling results in significant deficits in performance on both tasks. [1] |
| Molecular Weight | 388.42 |
| Formula | C22H20N4O3 |
| Cas No. | 1144504-35-7 |
| Smiles | OC(=O)c1cc(CN2CCC(CC2)(C#N)c2ccccn2)c2ccccn2c1=O |
| Relative Density. | 1.41 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: ＜1 mg/mL (insoluble or slightly soluble), Sonication and heating to 80℃ are recommended.  |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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