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Progabide

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Purity:99.7%

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COA HPLC HNMR

Progabide

Catalog No. T16581Cas No. 62666-20-0

Progabide (SL 76002) is an agonist of the gamma-aminobutyric acid receptor.

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Pack Size	Price	Availability
5 mg	$47	In Stock
10 mg	$80	In Stock
25 mg	$163	In Stock
50 mg	$263	In Stock
100 mg	$413	In Stock
200 mg	$590	In Stock
500 mg	$943	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock

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Product Introduction

Bioactivity

Description	Progabide (SL 76002) is an agonist of the gamma-aminobutyric acid receptor.
In vivo	Progabide ( 50, 100 and 200 mg/kg) given IP to male Wistar rats enhance the plasma corticosterone levels by 244, 365, and 476% respectively (t=6.44 to12.55, p<0.01). Progabide (10 mg/kg) fails to change the concentration of corticosterone in plasma (t=0.76, N.S.). The increased plasma corticosterone level induced by administration of 200 mg/kg Progabide is evident 30 (t=2.625, p<0.05), 60 (t=13.13, p<0.001) and 120 min (t=4.07, p<0.01) after drug injection, but returns to the control value 240 min after drug injection (t=0.86, N.S.). Compare with the corresponding control, The greatest corticosterone rise is reached 60 min following the administration of Progabide[1].
Alias	SL 76002, Halogabide, Gabren, Gabrene

Chemical Properties

Molecular Weight	334.77
Formula	C17H16ClFN2O2
Cas No.	62666-20-0

Storage & Solubility Information

Storage

keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 225 mg/mL (672.1 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9871 mL	14.9356 mL	29.8713 mL	149.3563 mL
5 mM	0.5974 mL	2.9871 mL	5.9743 mL	29.8713 mL
10 mM	0.2987 mL	1.4936 mL	2.9871 mL	14.9356 mL
20 mM	0.1494 mL	0.7468 mL	1.4936 mL	7.4678 mL
50 mM	0.0597 mL	0.2987 mL	0.5974 mL	2.9871 mL
100 mM	0.0299 mL	0.1494 mL	0.2987 mL	1.4936 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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