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RO6889678

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Purity:98.72%

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COA HPLC HNMR

RO6889678

Catalog No. T9054Cas No. 1578153-27-1

RO6889678 is HBV inhibitor with a complex ADME profile.

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Pack Size	Price	Availability
1 mg	$68	In Stock
2 mg	$98	In Stock
5 mg	$138	In Stock
10 mg	$198	In Stock
25 mg	$283	In Stock
50 mg	$452	In Stock
100 mg	$665	In Stock
1 mL x 10 mM (in DMSO)	$169	In Stock

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Product Introduction

Bioactivity

Description

RO6889678 is HBV inhibitor with a complex ADME profile.

In vitro

RO6889678, a novel inhibitor of HBV with a complex absorption, distribution, metabolism, and excretion (ADME) profile.?RO6889678 showed an intracellular enrichment of 78-fold in hepatocytes, with an apparent intrinsic clearance of 5.2 l/min per mg protein and uptake and biliary clearances of 2.6 and 1.6 l/min per mg protein, respectively.?When apparent intrinsic clearance was incorporated into a PBPK model, the simulated oral human profiles were in good agreement with observed data at low doses but were underestimated at high doses due to unexpected overproportional increases in exposure with dose.?In addition, the induction potential of RO6889678 on cytochrome P450 (P450) enzymes and transporters at steady state was assessed and cotreatment with ritonavir revealed a complex drug-drug interaction with concurrent P450 inhibition and moderate UDP-glucuronosyltransferase induction.

Chemical Properties

Molecular Weight	494.92
Formula	C21H20ClFN4O5S
Cas No.	1578153-27-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (111.13 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0205 mL	10.1026 mL	20.2053 mL	101.0264 mL
5 mM	0.4041 mL	2.0205 mL	4.0411 mL	20.2053 mL
10 mM	0.2021 mL	1.0103 mL	2.0205 mL	10.1026 mL
20 mM	0.1010 mL	0.5051 mL	1.0103 mL	5.0513 mL
50 mM	0.0404 mL	0.2021 mL	0.4041 mL	2.0205 mL
100 mM	0.0202 mL	0.1010 mL	0.2021 mL	1.0103 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc