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Savolitinib

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Purity:98.03%

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COA HNMR LCMS

Savolitinib

Catalog No. TQ0210Cas No. 1313725-88-0

Savolitinib (Volitinib) (AZD-6094) is an effective, selective, and orally bioavailable c-Met inhibitor (IC50s: 5 nM/3 nM for c-Met/p-Met).

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Pack Size	Price	Availability
1 mg	$42	In Stock
2 mg	$58	In Stock
5 mg	$93	In Stock
10 mg	$133	In Stock
25 mg	$222	In Stock
50 mg	$392	In Stock
100 mg	$597	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock

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Product Introduction

Bioactivity

Description	Savolitinib (Volitinib) (AZD-6094) is an effective, selective, and orally bioavailable c-Met inhibitor (IC50s: 5 nM/3 nM for c-Met/p-Met).
In vitro	Savolitinib selectively binds to and inhibits the activation of c-Met in an ATP-competitive manner, and disrupts c-Met signal transduction pathways [1,2].
In vivo	In a U87MG subcutaneous xenograft model, Savolitinib (1-10.0 mg/kg; oral administration; daily; for 21 days; athymic nude mice) demonstrates dose-dependent tumor growth inhibition. In addition, none of the mice in the dosing groups exhibits body weight loss during the experiment [1].
Alias	AZD-6094, Volitinib, HMPL-504

Chemical Properties

Molecular Weight	345.36
Formula	C17H15N9
Cas No.	1313725-88-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 32 mg/mL (92.65 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8955 mL	14.4776 mL	28.9553 mL	144.7765 mL
5 mM	0.5791 mL	2.8955 mL	5.7911 mL	28.9553 mL
10 mM	0.2896 mL	1.4478 mL	2.8955 mL	14.4776 mL
20 mM	0.1448 mL	0.7239 mL	1.4478 mL	7.2388 mL
50 mM	0.0579 mL	0.2896 mL	0.5791 mL	2.8955 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc