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Schisandrin C

🥰Excellent
Catalog No. T5S1923Cas No. 61301-33-5
Alias Wuweizisu-C, Schizandrin-C

Schisandrin C (Wuweizisu-C) is a phytochemical lignan isolated from Schizandra chinensis Baill; shows anticancer-effects in human leukemia U937 cells.

Schisandrin C

Schisandrin C

🥰Excellent
Purity: 99.56%
Catalog No. T5S1923Alias Wuweizisu-C, Schizandrin-CCas No. 61301-33-5
Schisandrin C (Wuweizisu-C) is a phytochemical lignan isolated from Schizandra chinensis Baill; shows anticancer-effects in human leukemia U937 cells.
Pack SizePriceAvailabilityQuantity
20 mg$90In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Purity:99.56%
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Product Introduction

Bioactivity
Description
Schisandrin C (Wuweizisu-C) is a phytochemical lignan isolated from Schizandra chinensis Baill; shows anticancer-effects in human leukemia U937 cells.
In vitro
Schisandrin C inhibited cell growth in a dose-dependent manner, which was associated with the induction of G1 arrest of the cell cycle and apoptosis. Schisandrin C induced G1 arrest was correlated with down-regulation of cyclin D1, cyclin E, cyclin-dependent kinase (Cdk) 4 and E2Fs expression, inhibition of phosphorylation of retinoblastoma protein (pRB), and up-regulation of the Cdk inhibitor p21(WAF1/CIP1). In addition, schisandrin C-induced apoptosis was associated with down-regulation of expression of the anti-apoptotic proteins Bcl-2 and Bcl-xL, proteolytic activation of caspase-3 and -9, and a concomitant degradation of poly(ADP-ribose) polymerase (PARP). Furthermore, schisandrin C-induced apoptosis was significantly inhibited by a caspase-3 specific inhibitor z-DEVD-fmk . Schisandrin C was found to reduce nitric oxide (NO) production from LPS-stimulated Raw 264.7 cells. Pre-treatment of Raw 264.7 cells with gomisin J, gomisin N, or schisandrin C reduced the expression of mRNA and the secretion of pro-inflammatory cytokines .
AliasWuweizisu-C, Schizandrin-C
Chemical Properties
Molecular Weight384.42
FormulaC22H24O6
Cas No.61301-33-5
SmilesCOc1c2OCOc2cc2CC(C)C(C)Cc3cc4OCOc4c(OC)c3-c12
Relative Density.1.232 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 25 mg/mL (65.03 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6013 mL13.0066 mL26.0132 mL130.0661 mL
5 mM0.5203 mL2.6013 mL5.2026 mL26.0132 mL
10 mM0.2601 mL1.3007 mL2.6013 mL13.0066 mL
20 mM0.1301 mL0.6503 mL1.3007 mL6.5033 mL
50 mM0.0520 mL0.2601 mL0.5203 mL2.6013 mL

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