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Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $39 | In Stock | |
25 mg | $72 | In Stock | |
50 mg | $118 | In Stock | |
100 mg | $189 | In Stock | |
200 mg | $278 | In Stock | |
1 mL x 10 mM (in DMSO) | $30 | In Stock |
Description | Setipiprant (ACT-129968) is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2, a G protein-coupled receptor for prostaglandin (PGD2), mediates key inflammatory responses related to allergy and asthma. PGD2, produced by mast cells, binds to CRTH2 on blood-borne cells, inducing chemotaxis of Th2 cells, basophils, and eosinophils, and stimulating cytokine release. |
Targets&IC50 | CRTH2:6.0 nM |
Alias | KYTH-105, ACT-129968 |
Molecular Weight | 402.42 |
Formula | C24H19FN2O3 |
Cas No. | 866460-33-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45 mg/mL (111.82 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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