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(1)
By Target- GPR
- Prostaglandin Receptor(1)
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Results for "
setipiprant
" in TargetMol Product Catalog- Inhibitors & Agonists1
Setipiprant
T3520866460-33-5
Setipiprant (ACT-129968) is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2, a G protein-coupled receptor for prostaglandin (PGD2), mediates key inflammatory responses related to allergy and asthma. PGD2, produced by mast cells, binds to CRTH2 on blood-borne cells, inducing chemotaxis of Th2 cells, basophils, and eosinophils, and stimulating cytokine release.
- $39
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