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Silybin B

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Purity:99.66%

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COA HPLC HNMR

Silybin B

Catalog No. TN2211Cas No. 142797-34-0

Silybin B (Silibinin B) is an effective inhibitor of raloxifene 4 '- and 6-glucosalylation, an effective anti-fibrinogenic and anti-oligomeric component of Silymarin, with free radical scavenging activity of 1, 1-diphenyl-2-pyridinyl hydrazine (DPPH), and a protective effect against cisplatin-induced neurotoxicity by alleviating DNA damage and apoptosis. Silybin B can inhibit the growth of human chronic myeloid leukemia K562 cells and induce apoptosis.

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Pack Size	Price	Availability
1 mg	$122	In Stock
5 mg	$328	In Stock
10 mg	$493	In Stock
25 mg	$788	In Stock
50 mg	Inquiry	In Stock
1 mL x 10 mM (in DMSO)	$349	In Stock

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Product Introduction

Bioactivity

Description	Silybin B (Silibinin B) is an effective inhibitor of raloxifene 4 '- and 6-glucosalylation, an effective anti-fibrinogenic and anti-oligomeric component of Silymarin, with free radical scavenging activity of 1, 1-diphenyl-2-pyridinyl hydrazine (DPPH), and a protective effect against cisplatin-induced neurotoxicity by alleviating DNA damage and apoptosis. Silybin B can inhibit the growth of human chronic myeloid leukemia K562 cells and induce apoptosis.
In vitro	The present study assessed the effects of the diastereoisomers on cell apoptosis, and compared these with their mixture, silybin, in human chronic myeloid leukemia K562 cells. Both isomers showed stronger effects on cell growth inhibition and apoptosis induction than silybin. Compared with Silybin B, silybin A showed higher effects on the production of intracellular reactive oxygen species and Ca2+.[1]
In vivo	Silybin B markedly improved the behavioral abnormalities in cisplatin-treated mice and reduced LPO levels while increasing SOD, GSH, and T-AOC in mice brain tissue. Nissl staining and Tunel assay showed that silybin B alleviated cisplatin-induced hippocampal damage.[2]
Alias	Silibinin B

Chemical Properties

Molecular Weight	482.44
Formula	C25H22O10
Cas No.	142797-34-0

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 225.0 mg/mL (466.4 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0728 mL	10.3640 mL	20.7280 mL	103.6398 mL
5 mM	0.4146 mL	2.0728 mL	4.1456 mL	20.7280 mL
10 mM	0.2073 mL	1.0364 mL	2.0728 mL	10.3640 mL
20 mM	0.1036 mL	0.5182 mL	1.0364 mL	5.1820 mL
50 mM	0.0415 mL	0.2073 mL	0.4146 mL	2.0728 mL
100 mM	0.0207 mL	0.1036 mL	0.2073 mL	1.0364 mL

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