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Sovleplenib
🥰Excellent
Catalog No. T32088Cas No. 1415792-84-5
Alias HMPL-523, HMPL523, HMPL 523
Sovleplenib (HMPL523) is an orally available, selective and potent inhibitor of the splenic tyrosine kinase SYK with an IC50 of 25 nM.Sovleplenib has antitumor activity and may be used in studies of immune thrombocytopenia (ITP).
Sovleplenib
🥰Excellent
Purity: 98.51%
Catalog No. T32088Alias HMPL-523, HMPL523, HMPL 523Cas No. 1415792-84-5
Sovleplenib (HMPL523) is an orally available, selective and potent inhibitor of the splenic tyrosine kinase SYK with an IC50 of 25 nM.Sovleplenib has antitumor activity and may be used in studies of immune thrombocytopenia (ITP).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $129 | In Stock | |
| 5 mg | $322 | In Stock | |
| 10 mg | $483 | In Stock | |
| 25 mg | $818 | In Stock | |
| 50 mg | $1,280 | In Stock | |
| 100 mg | $1,990 | In Stock | |
| 200 mg | $2,680 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $342 | In Stock |
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Purity:98.51%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Sovleplenib (HMPL523) is an orally available, selective and potent inhibitor of the splenic tyrosine kinase SYK with an IC50 of 25 nM.Sovleplenib has antitumor activity and may be used in studies of immune thrombocytopenia (ITP). |
| Targets&IC50 | Syk:25 nM |
| In vitro | Sovleplenib (HMPL-523) exhibits inhibitory activity with IC50 values of 0.025 μM, 0.063 μM, 0.390 μM, 0.921 μM, 3.214 μM, and 3.969 μM against SYK, FLT3, KDR, LYN, FGFR2, and AUR A, respectively.[2] Sovleplenib effectively blocks the phosphorylation of BLNK, a downstream protein of Syk, in human mantle cell line REC-1 and human plasma cell line ARH-7777, with IC50 values of 0.105 μM and 0.173 μM, respectively.[2] Sovleplenib also significantly reduces cell viability in Ba/F3 Tel-Syk cells with an IC50 of 0.033 μM and increases the rate of apoptosis in REC-1 cells.[2] Sovleplenib demonstrates synergistic effects in combination with other drugs, including BTK inhibitors, PI3Kδ inhibitors, and Bcl2 family inhibitors, in killing human-diffuse large B cell lymphoma (DLBCL).[2] |
| In vivo | Sovleplenib (HMPL-523) (10 and 100 mg/kg; once daily for 8 days; Balb/c nude mice with subcutaneously implanted REC-1 cells or intravenously injected BA/F3 cells or BA/F3 TEL-SYK cells) Inhibited tumor growth in REC-1 subcutaneous xenograft model at 100 mg/kg.[1] Sovleplenib (HMPL-523; 100 mg/kg; daily oral administration; for 8 days) shows potent anti-tumor activity in B cell lymphoma REC-1 (TGI: 59%) in Syk-dependent xenograft models.[2] |
| Alias | HMPL-523, HMPL523, HMPL 523 |
| Molecular Weight | 482.6 |
| Formula | C24H30N6O3S |
| Cas No. | 1415792-84-5 |
| Smiles | CS(=O)(=O)N1CCC(CC1)c1ccc(cc1)-c1cc2nccnc2c(NC[C@@H]2CNCCO2)n1 |
| Relative Density. | 1.37 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 14.48 mg/mL (30 mM), Sonication and heating are recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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