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SR-318

🥰Excellent
Catalog No. T12997Cas No. 2413286-32-3

SR-318 is a potent and highly selective inhibitor of p38 MAPK, demonstrating IC50 values of 5 nM for p38α, 32 nM for p38β, and 6.11 μM for p38α/β. It possesses both anti-cancer and anti-inflammatory activity.

SR-318

SR-318

🥰Excellent
Purity: 99.53%
Catalog No. T12997Cas No. 2413286-32-3
SR-318 is a potent and highly selective inhibitor of p38 MAPK, demonstrating IC50 values of 5 nM for p38α, 32 nM for p38β, and 6.11 μM for p38α/β. It possesses both anti-cancer and anti-inflammatory activity.
Pack SizePriceAvailabilityQuantity
2 mg$32 In Stock
5 mg$53 In Stock
10 mg$88 In Stock
25 mg$178 In Stock
50 mg$287 In Stock
100 mg$413 In Stock
200 mg$593 In Stock
1 mL x 10 mM (in DMSO)$53 In Stock
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Purity:99.53%
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Product Introduction

Bioactivity
Description
SR-318 is a potent and highly selective inhibitor of p38 MAPK, demonstrating IC50 values of 5 nM for p38α, 32 nM for p38β, and 6.11 μM for p38α/β. It possesses both anti-cancer and anti-inflammatory activity.
Targets&IC50
p38β:32 nM, p38α/β:6.11 μM, TNF-α:283 nM, p38α:5 nM
In vitro
SR-318 is a potent and selective type-II p38α/β inhibitor, utilized as a chemical probe to target the inactive state of these p38 isoforms [1].
Chemical Properties
Molecular Weight459.58
FormulaC27H33N5O2
Cas No.2413286-32-3
SmilesNc1c(cnn1-c1ccccc1)C(=O)NCc1ccc(cc1)C(=O)NCCCC1CCCCC1
Relative Density.1.24 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 125 mg/mL (271.99 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1759 mL10.8795 mL21.7590 mL108.7950 mL
5 mM0.4352 mL2.1759 mL4.3518 mL21.7590 mL
10 mM0.2176 mL1.0879 mL2.1759 mL10.8795 mL
20 mM0.1088 mL0.5440 mL1.0879 mL5.4397 mL
50 mM0.0435 mL0.2176 mL0.4352 mL2.1759 mL
100 mM0.0218 mL0.1088 mL0.2176 mL1.0879 mL

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