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SR-318 is a potent and highly selective inhibitor of p38 MAPK, demonstrating IC50 values of 5 nM for p38α, 32 nM for p38β, and 6.11 μM for p38α/β. It possesses both anti-cancer and anti-inflammatory activity.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $32 | In Stock | |
5 mg | $53 | In Stock | |
10 mg | $88 | In Stock | |
25 mg | $178 | In Stock | |
50 mg | $287 | In Stock | |
100 mg | $413 | In Stock | |
200 mg | $593 | In Stock | |
1 mL x 10 mM (in DMSO) | $53 | In Stock |
Description | SR-318 is a potent and highly selective inhibitor of p38 MAPK, demonstrating IC50 values of 5 nM for p38α, 32 nM for p38β, and 6.11 μM for p38α/β. It possesses both anti-cancer and anti-inflammatory activity. |
Targets&IC50 | p38β:32 nM, p38α/β:6.11 μM, TNF-α:283 nM, p38α:5 nM |
In vitro | SR-318 is a potent and selective type-II p38α/β inhibitor, utilized as a chemical probe to target the inactive state of these p38 isoforms [1]. |
Molecular Weight | 459.58 |
Formula | C27H33N5O2 |
Cas No. | 2413286-32-3 |
Smiles | Nc1c(cnn1-c1ccccc1)C(=O)NCc1ccc(cc1)C(=O)NCCCC1CCCCC1 |
Relative Density. | 1.24 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 125 mg/mL (271.99 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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