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SR0987

🥰Excellent
Catalog No. T4670Cas No. 303126-97-8

SR0987 is a RORγt agonist,

SR0987

SR0987

🥰Excellent
Purity: 99.43%
Catalog No. T4670Cas No. 303126-97-8
SR0987 is a RORγt agonist,
Pack SizePriceAvailabilityQuantity
5 mg$64In Stock
10 mg$113In Stock
25 mg$228In Stock
50 mg$397In Stock
100 mg$589In Stock
1 mL x 10 mM (in DMSO)$70In Stock
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Purity:99.43%
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Product Introduction

Bioactivity
Description
SR0987 is a RORγt agonist,
Targets&IC50
RORγt:800 nM (EC50)
In vitro
Treatment with SR0987 leads to a significant decrease in the surface expression of PD-1, while desmosterol shows no impact on this parameter. Co-treatment with SR0987 and desmosterol suggests a potential increase in IL17 production. Additionally, SR0987 exhibits a concentration-dependent stimulation of reporter gene expression, achieving an effective concentration (EC50) of approximately 800nM.
Chemical Properties
Molecular Weight397.7
FormulaC16H10ClF6NO2
Cas No.303126-97-8
SmilesOC(c1ccc(NC(=O)c2ccccc2Cl)cc1)(C(F)(F)F)C(F)(F)F
Relative Density.1.525 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 45 mg/mL (113.15 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5145 mL12.5723 mL25.1446 mL125.7229 mL
5 mM0.5029 mL2.5145 mL5.0289 mL25.1446 mL
10 mM0.2514 mL1.2572 mL2.5145 mL12.5723 mL
20 mM0.1257 mL0.6286 mL1.2572 mL6.2861 mL
50 mM0.0503 mL0.2514 mL0.5029 mL2.5145 mL
100 mM0.0251 mL0.1257 mL0.2514 mL1.2572 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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