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SR0987 is a RORγt agonist,
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $64 | In Stock | |
10 mg | $113 | In Stock | |
25 mg | $228 | In Stock | |
50 mg | $397 | In Stock | |
100 mg | $589 | In Stock | |
1 mL x 10 mM (in DMSO) | $70 | In Stock |
Description | SR0987 is a RORγt agonist, |
Targets&IC50 | RORγt:800 nM (EC50) |
In vitro | Treatment with SR0987 leads to a significant decrease in the surface expression of PD-1, while desmosterol shows no impact on this parameter. Co-treatment with SR0987 and desmosterol suggests a potential increase in IL17 production. Additionally, SR0987 exhibits a concentration-dependent stimulation of reporter gene expression, achieving an effective concentration (EC50) of approximately 800nM. |
Molecular Weight | 397.7 |
Formula | C16H10ClF6NO2 |
Cas No. | 303126-97-8 |
Smiles | OC(c1ccc(NC(=O)c2ccccc2Cl)cc1)(C(F)(F)F)C(F)(F)F |
Relative Density. | 1.525 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45 mg/mL (113.15 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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