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SW106065

SW106065
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Purity:99.96%
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SW106065

Catalog No. T8762Cas No. 62289-81-0
SW106065 is a novel pharmacologic inducer of apoptosis in MPNST (malignant peripheral nerve sheath tumors).SW106065 is an apoptosis inducer in malignant peripheral nerve sheath tumors (MPNST). It inhibits ATP consumption of sMPNST and other models of MPNST with an EC50 of 1 μM. SW106065 can be used for MPNST research
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Pack SizePriceAvailabilityQuantity
1 mg$31In Stock
5 mg$81In Stock
10 mg$129In Stock
25 mg$222In Stock
50 mg$322In Stock
100 mg$463In Stock
1 mL x 10 mM (in DMSO)$89In Stock
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Product Introduction

Bioactivity
Description
SW106065 is a novel pharmacologic inducer of apoptosis in MPNST (malignant peripheral nerve sheath tumors).SW106065 is an apoptosis inducer in malignant peripheral nerve sheath tumors (MPNST). It inhibits ATP consumption of sMPNST and other models of MPNST with an EC50 of 1 μM. SW106065 can be used for MPNST research
In vitro
SW-106065 inhibits growth of all available in vitro models of MPNST and human MPNST cell lines, while remaining nontoxic to normally dividing Schwann cells or mouse embryonic fibroblasts. We This compound delays the cell cycle and leads to cellular apoptosis.
In vivo
SW-106065 can reduce MPNST burden in a mouse allograft model, underscoring the compound's potential as a novel chemotherapeutic agent.
AliasSW-106065
Chemical Properties
Molecular Weight204.25
FormulaC10H8N2OS
Cas No.62289-81-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 96 mg/mL (470 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.8960 mL24.4798 mL48.9596 mL244.7980 mL
5 mM0.9792 mL4.8960 mL9.7919 mL48.9596 mL
10 mM0.4896 mL2.4480 mL4.8960 mL24.4798 mL
20 mM0.2448 mL1.2240 mL2.4480 mL12.2399 mL
50 mM0.0979 mL0.4896 mL0.9792 mL4.8960 mL
100 mM0.0490 mL0.2448 mL0.4896 mL2.4480 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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