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SYN1143

🥰Excellent
Catalog No. T8409Cas No. 913376-84-8
Alias RON-IN-1, AMG-1

SYN1143 (AMG-1) is a potent inhibitor of human RON and c-Met.In vitro kinase assays showed that compound I is a potent inhibitor of human RON and c-Met with IC50s of 9 and 4 nmol/L, respectively.

SYN1143

SYN1143

🥰Excellent
Purity: 98.86%
Catalog No. T8409Alias RON-IN-1, AMG-1Cas No. 913376-84-8
SYN1143 (AMG-1) is a potent inhibitor of human RON and c-Met.In vitro kinase assays showed that compound I is a potent inhibitor of human RON and c-Met with IC50s of 9 and 4 nmol/L, respectively.
Pack SizePriceAvailabilityQuantity
2 mg28 €In Stock
5 mg45 €In Stock
10 mg70 €In Stock
25 mg113 €In Stock
50 mg169 €In Stock
1 mL x 10 mM (in DMSO)56 €In Stock
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Purity:98.86%
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Product Introduction

Bioactivity
Description
SYN1143 (AMG-1) is a potent inhibitor of human RON and c-Met.In vitro kinase assays showed that compound I is a potent inhibitor of human RON and c-Met with IC50s of 9 and 4 nmol/L, respectively.
Targets&IC50
c-Met:4 nM, RON:9 nM
AliasRON-IN-1, AMG-1
Chemical Properties
Molecular Weight556.58
FormulaC31H29FN4O5
Cas No.913376-84-8
SmilesCOc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 90 mg/mL (161.7 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7967 mL8.9834 mL17.9669 mL89.8343 mL
5 mM0.3593 mL1.7967 mL3.5934 mL17.9669 mL
10 mM0.1797 mL0.8983 mL1.7967 mL8.9834 mL
20 mM0.0898 mL0.4492 mL0.8983 mL4.4917 mL
50 mM0.0359 mL0.1797 mL0.3593 mL1.7967 mL
100 mM0.0180 mL0.0898 mL0.1797 mL0.8983 mL

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