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TCN 213
🥰Excellent
Catalog No. T8450Cas No. 556803-08-8
Alias TCN213
TCN 213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2B
TCN 213
🥰Excellent
Purity: 99.68%
Catalog No. T8450Alias TCN213Cas No. 556803-08-8
TCN 213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2B
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | 36 € | In Stock | |
| 5 mg | 57 € | In Stock | |
| 10 mg | 93 € | In Stock | |
| 25 mg | 188 € | In Stock | |
| 50 mg | 311 € | In Stock | |
| 100 mg | 511 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 37 € | In Stock |
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Purity:99.68%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | TCN 213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2B |
| Targets&IC50 | GluN1/GluN2A NMDAR:0.55-40 μM (IC50) |
| In vitro | TCN 213 antagonism of GluN1/GluN2A NMDA receptors was dependent on glycine but independent of glutamate concentrations in external recording solutions.?Antagonism by TCN 213 was surmountable and gave a Schild plot with unity slope.?TCN 213 block of GluN1/GluN2B NMDA receptor-mediated currents was negligible.?In cortical neurones, at a early developmental stage predominantly expressing GluN2B-containing NMDA receptors, TCN 213 failed to antagonize NMDA receptor-mediated currents or to prevent GluN2B-dependent, NMDA-induced excitoxicity.?In older cultures (DIV 14) or in neurones transfected with GluN2A subunits, TCN 213 antagonized NMDA-evoked currents.?Block by TCN 213 of NMDA currents inversely correlated with block by ifenprodil, a selective GluN2B antagonist. |
| Alias | TCN213 |
| Molecular Weight | 376.54 |
| Formula | C18H24N4OS2 |
| Cas No. | 556803-08-8 |
| Smiles | O=C(CSc1nnc(NCc2ccccc2)s1)NCC1CCCCC1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (79.67 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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