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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $44 | In Stock | |
5 mg | $97 | In Stock | |
10 mg | $155 | In Stock | |
25 mg | $313 | In Stock | |
50 mg | $513 | In Stock | |
100 mg | $747 | In Stock | |
1 mL x 10 mM (in DMSO) | $113 | In Stock |
Description | TCN 213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2B |
Targets&IC50 | GluN1/GluN2A NMDAR:0.55-40 μM (IC50) |
In vitro | TCN 213 antagonism of GluN1/GluN2A NMDA receptors was dependent on glycine but independent of glutamate concentrations in external recording solutions.?Antagonism by TCN 213 was surmountable and gave a Schild plot with unity slope.?TCN 213 block of GluN1/GluN2B NMDA receptor-mediated currents was negligible.?In cortical neurones, at a early developmental stage predominantly expressing GluN2B-containing NMDA receptors, TCN 213 failed to antagonize NMDA receptor-mediated currents or to prevent GluN2B-dependent, NMDA-induced excitoxicity.?In older cultures (DIV 14) or in neurones transfected with GluN2A subunits, TCN 213 antagonized NMDA-evoked currents.?Block by TCN 213 of NMDA currents inversely correlated with block by ifenprodil, a selective GluN2B antagonist. |
Alias | TCN213 |
Molecular Weight | 376.54 |
Formula | C18H24N4OS2 |
Cas No. | 556803-08-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 30 mg/mL (79.67 mM) ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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