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(E/Z)-Teriflunomide
Catalog No. T3044Cas No. 108605-62-5
Alias HMR-1726, Flucyamide, Aubagio, A77 1726
(E/Z)-Teriflunomide (Aubagio), a orally-available Pyrimidine Synthesis Inhibitor, is used to treat relapsing multiple sclerosis.
(E/Z)-Teriflunomide
Catalog No. T3044Alias HMR-1726, Flucyamide, Aubagio, A77 1726Cas No. 108605-62-5
(E/Z)-Teriflunomide (Aubagio), a orally-available Pyrimidine Synthesis Inhibitor, is used to treat relapsing multiple sclerosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 mg | $31 | In Stock | |
| 100 mg | $48 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock |
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Purity:99.76%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | (E/Z)-Teriflunomide (Aubagio), a orally-available Pyrimidine Synthesis Inhibitor, is used to treat relapsing multiple sclerosis. |
| In vitro | In animal models of demyelinating diseases, Teriflunomide has demonstrated efficacy. For instance, in the black rat model of autoimmune encephalomyelitis, Teriflunomide has shown both preventive and therapeutic effects; similarly, in female Lewis rat models of Experimental Autoimmune Encephalomyelitis (EAE), it has been effective in ameliorating symptoms and reducing disease exacerbation. |
| In vivo | Teriflunomide acts as a dihydroorotate dehydrogenase inhibitor, thereby inhibiting the de novo synthesis of pyrimidine in rapidly proliferating cells. By suppressing highly proliferative T and B lymphocytes, Teriflunomide effectively reduces the inflammatory response to self-antigens. |
| Alias | HMR-1726, Flucyamide, Aubagio, A77 1726 |
| Molecular Weight | 270.21 |
| Formula | C12H9F3N2O2 |
| Cas No. | 108605-62-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 6.25 mg/mL (23.13 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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