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Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $39 | In Stock | |
25 mg | $79 | In Stock | |
50 mg | $118 | In Stock | |
100 mg | $173 | In Stock | |
500 mg | $438 | In Stock | |
1 mL x 10 mM (in DMSO) | $43 | In Stock |
Description | Tetrac (Tetraiodothyroacetic acid) is a derivative of L-thyroxine (T4), a thyroxine integrin receptor antagonist.Tetrac induces antiproliferation by blocking EGFR-mediated cell signaling in colorectal cancer cells.Tetrac blocks the effects of T4 and 3,5,3'-triiodo-L-thyronine (T3) on the cell-surface thyroxine integrin αvβ3 receptors.Tetra has anti-angiogenic, anti-tumor activity and pro-apoptotic activity. |
In vitro | Tetrac (0.01-1 μM; 2-6 d) induces anti-proliferation in HT-29 and HCT116 cells with different K-RAS status, inhibits ERK1/2 activation (0.1 μM; 30 min), and modulates expression of CCND1, c-Myc, CASP2, and THBS1 (0.1 μM; 24 h), as demonstrated by cell proliferation assays in HT-29 and HCT116 cells[3]. |
In vivo | Tetrac (35 μg/day; p.o.; for 40 days; Wild-type male Balb/C mice inoculated with 102B16F10 or B16LS9 cells) delayed the onset of ocular melanoma and reduced the S-100 and integrin staining levels. Tetrac can inhibit tumor inoculation, growth, and integrin expression in mice.[4] |
Alias | Tetraiodothyroacetic acid, 3,3',5,5'-Tetraiodothyroacetic acid |
Molecular Weight | 747.83 |
Formula | C14H8I4O4 |
Cas No. | 67-30-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45 mg/mL (60.17 mM), Sonication is recommended. ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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