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Tubulin inhibitor 32
🥰Excellent
Catalog No. T78701Cas No. 2923531-39-7
Tubulin inhibitor 32 is an orally active novel microtubule inhibitor with antiproliferative and antitumor activity, inhibits microtubule polymerization, induces apoptosis and cell cycle arrest in G2/M phase.
Tubulin inhibitor 32
🥰Excellent
Purity: 99.34%
Catalog No. T78701Cas No. 2923531-39-7
Tubulin inhibitor 32 is an orally active novel microtubule inhibitor with antiproliferative and antitumor activity, inhibits microtubule polymerization, induces apoptosis and cell cycle arrest in G2/M phase.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | In Stock | |
| 5 mg | $722 | In Stock | |
| 10 mg | $987 | In Stock | |
| 25 mg | $1,520 | In Stock | |
| 50 mg | $1,980 | In Stock |
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Purity:99.34%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Tubulin inhibitor 32 is an orally active novel microtubule inhibitor with antiproliferative and antitumor activity, inhibits microtubule polymerization, induces apoptosis and cell cycle arrest in G2/M phase. |
| Targets&IC50 | Hela:24.61 µM, SW480:37.53 µM, HepG2:1.54 µM, MDA-MB-231:11.41 µM |
| In vitro | In HepG2, SW480, Hela, and MDA-MB-231 cells, Tubulin inhibitor 32 (0-64 µM; 48 hours) exhibited anti-proliferative activity, with IC50 values of 1.54, 37.53, 24.61, and 11.41 µM, respectively[1]. |
| In vivo | In 4-6 weeks old male nude mice (HCT-116 tumor model), Tubulin inhibitor 32 (50, 100 mg/kg; oral administration; once daily for 20 days) decreased the tumor volume and tumor weight by 44.1% and 27.0%, respectively[1]. |
| Molecular Weight | 325.36 |
| Formula | C18H19N3O3 |
| Cas No. | 2923531-39-7 |
| Smiles | N1=CC=C(C=2C=C(OC)C(OC)=C(OC)C2)N1C3=CC=C(N)C=C3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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