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UCM-1306
🥰Excellent
Catalog No. T67729Cas No. 2258608-78-3
UCM-1306 is a potent and orally active allosteric modulator (PAM) of the human dopamine D1 receptor. It increases the maximal effect of endogenous dopamine (DA) in both human and mouse D1 receptors. UCM-1306 could improve motor symptoms and address key comorbid cognitive impairment associated with long-term Parkinson's disease (PD).
UCM-1306
🥰Excellent
Purity: 100%
Catalog No. T67729Cas No. 2258608-78-3
UCM-1306 is a potent and orally active allosteric modulator (PAM) of the human dopamine D1 receptor. It increases the maximal effect of endogenous dopamine (DA) in both human and mouse D1 receptors. UCM-1306 could improve motor symptoms and address key comorbid cognitive impairment associated with long-term Parkinson's disease (PD).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $31 | In Stock | |
| 5 mg | $73 | In Stock | |
| 10 mg | $118 | In Stock | |
| 25 mg | $238 | In Stock | |
| 50 mg | $353 | In Stock | |
| 100 mg | $506 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | UCM-1306 is a potent and orally active allosteric modulator (PAM) of the human dopamine D1 receptor. It increases the maximal effect of endogenous dopamine (DA) in both human and mouse D1 receptors. UCM-1306 could improve motor symptoms and address key comorbid cognitive impairment associated with long-term Parkinson's disease (PD). |
| In vitro | UCM-1306 (1-10 μM) enhances CAMP in a concentration-response manner, EC50=60 nM[1]. |
| In vivo | UCM-1306 (p.o.; C57BL/6J mice) has good brain penetration and oral availability. The plasma concentration can be quantified within 8 hours, and Tmax is 0.5 hours. UCM-1306 (1 mg/kg; ip) enhances cocaine induced hyperactivity in adult mice. UCM-1306 (1 mg/kg; ip) helps to consolidate the formation of long-term memory [1]. |
| Molecular Weight | 279.33 |
| Formula | C14H14FNO2S |
| Cas No. | 2258608-78-3 |
| Smiles | CS(=N)(=O)c1ccc(cc1)-c1ccccc1OCF |
| Relative Density. | 1.21 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45.0 mg/mL (161.1 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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