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UNC2541
UNC2541 is a potent and specific inhibitor of Mer tyrosine kinase (MerTK), binding in the MerTK ATP pocket (IC50: 4.4 nM) and inhibiting phosphorylated MerTK (pMerTK) with an EC50 of 510 nM.
Catalog No. T17205Cas No. 1612782-86-1
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Purity:98.33%
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UNC2541
Catalog No. T17205Cas No. 1612782-86-1
UNC2541 is a potent and specific inhibitor of Mer tyrosine kinase (MerTK), binding in the MerTK ATP pocket (IC50: 4.4 nM) and inhibiting phosphorylated MerTK (pMerTK) with an EC50 of 510 nM.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $39 | In Stock | |
| 10 mg | $65 | In Stock | |
| 25 mg | $140 | In Stock | |
| 50 mg | $198 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $42 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | UNC2541 is a potent and specific inhibitor of Mer tyrosine kinase (MerTK), binding in the MerTK ATP pocket (IC50: 4.4 nM) and inhibiting phosphorylated MerTK (pMerTK) with an EC50 of 510 nM. |
| Targets&IC50 | Tyro3:220 nM , Axl:120 nM, FLT3:320 nM ) , pMer TK:510 nM(EC50) |
| Molecular Weight | 471.57 |
| Formula | C24H34FN7O2 |
| Cas No. | 1612782-86-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (21.21 mM), Sonication and heating to 60℃ are recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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