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VGX-1027

VGX-1027
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Purity:99.54%
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VGX-1027

Catalog No. T1813Cas No. 6501-72-0
VGX-1027 (GIT 27) is an isoxazole compound with various immunomodulatory properties.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
5 mg$42In Stock
10 mg$68In Stock
25 mg$142In Stock
50 mg$229In Stock
100 mg$367In Stock
1 mL x 10 mM (in DMSO)$46In Stock
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Product Introduction

Bioactivity
Description
VGX-1027 (GIT 27) is an isoxazole compound with various immunomodulatory properties.
In vitro
VGX-1027 enhances survival rates and ameliorates clinical and histopathological signs in the NZB/NZW F1 model of systemic lupus erythematosus, thereby improving disease progression. It prevents the spontaneous development of Type 1 diabetes in NOD mice and counters the acceleration of diabetes induced either by cyclophosphamide assault or by the adoptive transfer of diabetogenic spleen cells in NOD mice. Furthermore, VGX-1027 reduces clinical symptoms of diabetes induced by MLD-STZ and inhibits pathological histological changes in the pancreas.
In vivo
VGX-1027 exhibits inhibitory effects on the proliferation of gut bacterial antigen-reactive CD4+ CD25- T cells in vitro. It significantly suppresses the accumulation of TNF-α and nitrites induced by IL-1β/IFN-γ, and notably enhances cell survival by interfering with the toxic effects of cytokines.
AliasVGX1027, VGX 1027, GIT 27
Chemical Properties
Molecular Weight205.21
FormulaC11H11NO3
Cas No.6501-72-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 20.5 mg/mL (100 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.8731 mL24.3653 mL48.7306 mL243.6528 mL
5 mM0.9746 mL4.8731 mL9.7461 mL48.7306 mL
10 mM0.4873 mL2.4365 mL4.8731 mL24.3653 mL
20 mM0.2437 mL1.2183 mL2.4365 mL12.1826 mL
50 mM0.0975 mL0.4873 mL0.9746 mL4.8731 mL
100 mM0.0487 mL0.2437 mL0.4873 mL2.4365 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
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