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Visomitin

🥰Excellent
Catalog No. T4168Cas No. 934826-68-3
Alias SKQ1

Visomitin (SKQ1) is a mitochondria-targeted antioxidant that decreases transmembrane potential and production of reactive oxygen species (ROS).

Visomitin

Visomitin

🥰Excellent
Purity: 98%
Catalog No. T4168Alias SKQ1Cas No. 934826-68-3
Visomitin (SKQ1) is a mitochondria-targeted antioxidant that decreases transmembrane potential and production of reactive oxygen species (ROS).
Pack SizePriceAvailabilityQuantity
5 mg$43In Stock
10 mg$68In Stock
25 mg$126In Stock
50 mg$207In Stock
100 mg$365In Stock
1 mL x 10 mM (in DMSO)$59In Stock
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Purity:98%
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Product Introduction

Bioactivity
Description
Visomitin (SKQ1) is a mitochondria-targeted antioxidant that decreases transmembrane potential and production of reactive oxygen species (ROS).
In vitro
Direct treatment of tumor infiltrating leukocytes with Visomitin (SkQ1) does not influence their cytotoxicity against Panc02 cells. Visomitin reduces heavily the proliferation of human PDAC cells at 500 nM concentration while not affecting the viability of the cell lines.
In vivo
In a study on pancreatic ductal adenocarcinoma (PDAC)-bearing mice, continuous treatment with Visomitin (SkQ1) was found to modify systemic angiogenic factors. Specifically, this treatment led to a decrease in serum KC levels and an increase in VEGF molecules, indicating altered angiogenesis. Additionally, Visomitin treatment resulted in reduced levels of MIP1a and prolactin, alongside elevated amounts of IL-6 and IL-13. The pretreatment setting showed a decrease in TGF-b levels. Contrarily, Visomitin treatment across all protocols reduced the percentage of NKT cells. Although the median survival of PDAC-bearing mice was prolonged with Visomitin treatment, the survival increase did not achieve statistical significance.
Cell Research
Panc02 cells are treated 48 h with different concentrations of Visomitin (SkQ1). Cell viability after Visomitin treatment is measured with an EZ4U Kit as described by the manufacturers. Brie?y, 20,000 cells per well are seeded in 96-wellplates and let grow overnight. Afterwards, cells are treated without the medium exchange. A substrate compound from the kit is added and the cells are further incubated for 5 hr at 37°C to convert the yellow colored tetrazolium to its red formazan derivate by living cells. The absorbance is measured at 450 nm
Animal Research
Female C57BL/6 mice are used in this study. For experiments on both acute and chronic pancreatitis, mice are divided in three groups. Group A (acute pancreatitis (AP) n=8; chronic pancreatitis (CP) n=12) is treated with 5?nmol/kg Visomitin (SkQ1), group B (AP n=8; CP n=12) is the untreated control, and group C (AP n=8; CP n=7) is the sham group, which is injected intraperitoneally with 0.9% NaCl instead of cerulein and is therefore the negative control group without pancreatitis. For experiments on acute pancreatitis, mice are pretreated with Visomitin for 8 weeks prior to induction of pancreatitis. Mice designated for experiments on chronic pancreatitis receive Visomitin at the same concentration for 8 weeks in parallel with induction of pancreatitis
AliasSKQ1
Chemical Properties
Molecular Weight617.61
FormulaC36H42BrO2P
Cas No.934826-68-3
SmilesO=C1C(=CC(=O)C(=C1C)C)CCCCCCCCCC[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-]
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (89.05 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.6191 mL8.0957 mL16.1914 mL80.9572 mL
5 mM0.3238 mL1.6191 mL3.2383 mL16.1914 mL
10 mM0.1619 mL0.8096 mL1.6191 mL8.0957 mL
20 mM0.0810 mL0.4048 mL0.8096 mL4.0479 mL
50 mM0.0324 mL0.1619 mL0.3238 mL1.6191 mL

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