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XRP44X

🥰Excellent
Catalog No. T20759Cas No. 729605-21-4
Alias XRP-44-X, XRP-44X, XRP 44X, XRP 44 X

XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.

XRP44X

XRP44X

🥰Excellent
Purity: 97.51%
Catalog No. T20759Alias XRP-44-X, XRP-44X, XRP 44X, XRP 44 XCas No. 729605-21-4
XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.
Pack SizePriceAvailabilityQuantity
10 mg$50In Stock
25 mg$73In Stock
50 mg$113In Stock
1 mL x 10 mM (in DMSO)$51In Stock
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Purity:97.51%
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Product Introduction

Bioactivity
Description
XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.
Targets&IC50
Ras:10 nM
In vitro
XRP44X is an indirect inhibitor of Net phosphorylation, acting upstream of Erk-1/2 activation. XRP44X inhibits luciferase activity with an IC50 of approximately 10 nM[1]. At 10 nM, XRP44X inhibits the growth of HUVEC, NIH3T3, HCT-116, and NIH3T3–Ki-Ras cells[1]. At 100 nM, it inhibits phosphorylation of Mek-1/2 and Raf-1[1].
In vivo
XRP44X, an inhibitor of Ras/Erk activation of the transcription factor Elk3, demonstrates therapeutic potential for refractory asthma[1] by reducing tumor growth and metastasis in nude mice[2].
AliasXRP-44-X, XRP-44X, XRP 44X, XRP 44 X
Chemical Properties
Molecular Weight380.87
FormulaC21H21ClN4O
Cas No.729605-21-4
SmilesC(=O)(C=1N(N=C(C)C1)C2=CC=CC=C2)N3CCN(CC3)C4=CC(Cl)=CC=C4
Relative Density.1.27 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 36.67 mg/ml (96.27 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6256 mL13.1278 mL26.2557 mL131.2784 mL
5 mM0.5251 mL2.6256 mL5.2511 mL26.2557 mL
10 mM0.2626 mL1.3128 mL2.6256 mL13.1278 mL
20 mM0.1313 mL0.6564 mL1.3128 mL6.5639 mL
50 mM0.0525 mL0.2626 mL0.5251 mL2.6256 mL

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