Shopping Cart
- Remove All
![TargetMol](https://www.targetmol.com/storage/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $50 | In Stock | |
25 mg | $73 | In Stock | |
50 mg | $113 | In Stock | |
1 mL x 10 mM (in DMSO) | $51 | In Stock |
Description | XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway. |
In vitro | XRP44X is an indirect inhibitor of Net phosphorylation that acts upstream from Erk-1/2 activation. XRP44X inhibits luciferase activity with the IC50 of~10 nM[1]. XRP44X (10 nM) inhibits cell growth of HUVEC, NIH3T3, HCT-116, and NIH3T3–Ki-Ras cells[1]. XRP44X (100 nM) inhibits phosphorylation of Mek-1/2 and Raf-1[1]. |
In vivo | XRP44X may have therapeutic potential for refractory asthma[1]. XRP44X, an inhibitor of Ras/Erk activation of the transcription factor Elk3, inhibits tumor growth and metastasis in mice. XRP44X inhibits tumor growth and metastasis in nude mice. XRP44X decreases the growth of tumours and the formation of metastases in nude mice[2]. |
Alias | XRP-44-X, XRP 44X, XRP-44X, XRP 44 X |
Molecular Weight | 380.87 |
Formula | C21H21ClN4O |
Cas No. | 729605-21-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 36.67 mg/ml (96.27 mM) ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.