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XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $50 | In Stock | |
25 mg | $73 | In Stock | |
50 mg | $113 | In Stock | |
1 mL x 10 mM (in DMSO) | $51 | In Stock |
Description | XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway. |
Targets&IC50 | Ras:10 nM |
In vitro | XRP44X is an indirect inhibitor of Net phosphorylation, acting upstream of Erk-1/2 activation. XRP44X inhibits luciferase activity with an IC50 of approximately 10 nM[1]. At 10 nM, XRP44X inhibits the growth of HUVEC, NIH3T3, HCT-116, and NIH3T3–Ki-Ras cells[1]. At 100 nM, it inhibits phosphorylation of Mek-1/2 and Raf-1[1]. |
In vivo | XRP44X, an inhibitor of Ras/Erk activation of the transcription factor Elk3, demonstrates therapeutic potential for refractory asthma[1] by reducing tumor growth and metastasis in nude mice[2]. |
Alias | XRP-44-X, XRP-44X, XRP 44X, XRP 44 X |
Molecular Weight | 380.87 |
Formula | C21H21ClN4O |
Cas No. | 729605-21-4 |
Smiles | C(=O)(C=1N(N=C(C)C1)C2=CC=CC=C2)N3CCN(CC3)C4=CC(Cl)=CC=C4 |
Relative Density. | 1.27 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 36.67 mg/ml (96.27 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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