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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $101 | In Stock | |
5 mg | $223 | In Stock | |
10 mg | $397 | In Stock | |
25 mg | $665 | In Stock | |
50 mg | $947 | In Stock | |
100 mg | $1,280 | In Stock | |
1 mL x 10 mM (in DMSO) | $233 | In Stock |
Description | Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0 μM, respectively). |
In vivo | In the Dahl SS rat, Zamicastat (10, 30 and 100 mg/kg/day; oral bolus, 7 days) is tested acutely against salt-induced hypertension. Zamicastat produces a dose-dependent decrease in blood pressure[2]. |
Alias | BIA 5-1058 |
Molecular Weight | 401.47 |
Formula | C21H21F2N3OS |
Cas No. | 1080028-80-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 150 mg/mL (373.63 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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