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(-)-Securinine
🥰Excellent
Catalog No. T3S2100Cas No. 5610-40-2
Alias Securinine
(-)-Securinine (Securinine) is plant-derived alkaloid and also a GABAA receptor antagonist.
(-)-Securinine
🥰Excellent
Purity: 99.87%
Catalog No. T3S2100Alias SecurinineCas No. 5610-40-2
(-)-Securinine (Securinine) is plant-derived alkaloid and also a GABAA receptor antagonist.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $50 | In Stock | |
| 10 mg | $83 | In Stock | |
| 25 mg | $173 | In Stock | |
| 50 mg | $254 | In Stock | |
| 100 mg | $381 | In Stock |
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Purity:99.87%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | (-)-Securinine (Securinine) is plant-derived alkaloid and also a GABAA receptor antagonist. |
| In vitro | (-)-Securinine significantly inhibits HeLa cells growth with IC50 values of 7.02±0.52 μg/mL (32.3 μM). (-)-Securinine induces apoptosis in a dose-dependent manner in the tested cells, increases the percentage of ROS positive cells and depolarized cells as well as stimulates the activity of ERK1/2, caspase-9 and -3/7. (-)-Securinine also induces cell cycle arrest in S phase. Real-time PCR analysis shows high expression of tumor necrosis factor receptor superfamily (TNFRSF) genes in the cells stimulated with (-)-Securinine. |
| In vivo | In the tumor model, treatment with (-)-Securinine markedly inhibits tumor growth, suggesting its potential as an Acute Myeloid Leukemia (AML) treatment. Mice treated with (-)-Securinine (n=5 mice, bilateral tumors) show tumors that are, on average, over 75% smaller than those in vehicle-treated mice at the conclusion of the study. |
| Alias | Securinine |
| Molecular Weight | 217.26 |
| Formula | C13H15NO2 |
| Cas No. | 5610-40-2 |
| Smiles | [H][C@]12C[C@@]3(OC(=O)C=C3C=C1)[C@@]1([H])CCCCN21 |
| Relative Density. | 1.30 g/cm3 at 20℃ |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | DMSO: 2 mg/mL (9.21 mM) | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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