Powder: -20°C for 3 years | In solvent: -80°C for 1 year
4EGI-1, a competitive eIF4E/eIF4 g interaction inhibitor, binds to eIF4E(KD=25 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 37.00 | |
2 mg | In stock | $ 50.00 | |
5 mg | In stock | $ 90.00 | |
10 mg | In stock | $ 117.00 | |
25 mg | In stock | $ 231.00 | |
50 mg | In stock | $ 369.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 98.00 |
Description | 4EGI-1, a competitive eIF4E/eIF4 g interaction inhibitor, binds to eIF4E(KD=25 μM). |
Targets&IC50 | eIF4E/eIF4G:25 μM(Kd) |
Cell Research | Cell viability is measured by treatment of Jurkat cells with compound for 24 h and by determination of intracellular ATP using the CellTiterGlo assay. For measurement of apoptotic DNA fragmentation, cells are treated for 24 h with 60 μM EGI-1 or 6.65 μM camptothecin in the presence or absence of 100 mM zVAD-FMK, a broad-spectrum caspase inhibitor. After fixation and staining with PI, cellular DNA content is determined by FACS analysis in a FACS Calibur machine. Nuclear morphology after 24 h EG1-1 treatment is visualized by staining of cells with Hoechst dye and ?uorescence microscopy. For the A549 lung cancer cells, cell growth in the presence of 4EGI-1 is determined using the SRB staining method.(Only for Reference) |
Synonyms | 4EGI 1 |
Molecular Weight | 451.28 |
Formula | C18H12Cl2N4O4S |
CAS No. | 315706-13-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.1 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
4EGI-1 315706-13-9 Apoptosis Autophagy PERK 4EGI1 inhibit Eukaryotic Initiation Factor (eIF) 4EGI 1 Inhibitor inhibitor