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4EGI-1

Catalog No. T2665   CAS 315706-13-9
Synonyms: 4EGI 1

4EGI-1, a competitive eIF4E/eIF4 g interaction inhibitor, binds to eIF4E(KD=25 μM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
4EGI-1 Chemical Structure
4EGI-1, CAS 315706-13-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 37.00
2 mg In stock $ 50.00
5 mg In stock $ 90.00
10 mg In stock $ 117.00
25 mg In stock $ 231.00
50 mg In stock $ 369.00
1 mL * 10 mM (in DMSO) In stock $ 98.00
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Purity: 99.12%
Purity: 96.8%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 4EGI-1, a competitive eIF4E/eIF4 g interaction inhibitor, binds to eIF4E(KD=25 μM).
Targets&IC50 eIF4E/eIF4G:25 μM(Kd)
Cell Research Cell viability is measured by treatment of Jurkat cells with compound for 24 h and by determination of intracellular ATP using the CellTiterGlo assay. For measurement of apoptotic DNA fragmentation, cells are treated for 24 h with 60 μM EGI-1 or 6.65 μM camptothecin in the presence or absence of 100 mM zVAD-FMK, a broad-spectrum caspase inhibitor. After fixation and staining with PI, cellular DNA content is determined by FACS analysis in a FACS Calibur machine. Nuclear morphology after 24 h EG1-1 treatment is visualized by staining of cells with Hoechst dye and ?uorescence microscopy. For the A549 lung cancer cells, cell growth in the presence of 4EGI-1 is determined using the SRB staining method.(Only for Reference)
Synonyms 4EGI 1
Molecular Weight 451.28
Formula C18H12Cl2N4O4S
CAS No. 315706-13-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45.1 mg/mL (100 mM)

TargetMolReferences and Literature

1. Moerke NJ, et al. Cell. 2007, 128(2), 257-267. 2. Fan S, et al. Neoplasia. 2010, 12(4), 346-356. 3. Willimott S, et al. Clin Cancer Res. 2013, 19(12), 3212-3223.

TargetMolCitations

1. Berthier A, Gheeraert C, Johanns M, et al.The Molecular Circadian Clock Is a Target of Anti-cancer Translation Inhibitors.Journal of Biological Rhythms.2023: 07487304231202561.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library NO PAINS Compound Library Anti-Aging Compound Library Preclinical Compound Library PPI Inhibitor Library Kinase Inhibitor Library Anti-Cancer Compound Library Glutamine Metabolism Compound Library Reprogramming Compound Library Inhibitor Library

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Keywords

4EGI-1 315706-13-9 Apoptosis Autophagy PERK 4EGI1 inhibit Eukaryotic Initiation Factor (eIF) 4EGI 1 Inhibitor inhibitor

 

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