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9-Methoxycamptothecin
🥰Excellent
Catalog No. T5S1952Cas No. 39026-92-1
9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition.
9-Methoxycamptothecin
🥰Excellent
Purity: 99.55%
Catalog No. T5S1952Cas No. 39026-92-1
9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $48 | In Stock | |
| 50 mg | $72 | In Stock |
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Purity:99.55%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | 9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition. |
| In vitro | 9-Methoxycamptothecin(MCPT) induced cytotoxicity in seven human cancer cell lines in a dose dependent manner after 72h, with A2780 and Hela cell lines more sensitive, so the two cell lines were chosen to do further studies. MCPT induced strong G2/M arrest in both A2780 cells and Hela cells after 24h, following by substantial sub-G1 arrest (indicating apoptosis). The apoptosis was verified by staining with Annexin V-FITC and propidium iodide. ROS generation increased significantly in MCPT-induced apoptosis. Meanwhile, the apoptosis appeared to be dependent on caspase-3, -8 and -9 in A2780 cells, and caspase-3 in Hela cells. In addition, MCPT induced up-regulation expression of most of seventeen genes in both cell lines. Western blot verified that changes of TNFα, Fas, P53 and P27 protein level were consistent with their gene expression changes[1]. |
| Molecular Weight | 378.38 |
| Formula | C21H18N2O5 |
| Cas No. | 39026-92-1 |
| Smiles | CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cccc(OC)c4cc3Cn1c2=O |
| Relative Density. | 1.5g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (132.14 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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