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Acumapimod

Catalog No. T7367 CAS 836683-15-9

Synonyms: BCT-197

Acumapimod (BCT-197) is an orally active inhibitor of p38α MAPK (IC50 <1 μM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Acumapimod, CAS 836683-15-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
2 mg	In stock	$ 48.00
5 mg	In stock	$ 80.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 198.00
50 mg	In stock	$ 369.00
100 mg	In stock	$ 549.00
1 mL * 10 mM (in DMSO)	In stock	$ 89.00

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Purity: 98%

Biological Description

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Description	Acumapimod (BCT-197) is an orally active inhibitor of p38α MAPK (IC50 <1 μM).
Targets&IC50	p38α:<1 μM
In vivo	Acumapimod increases survival and reduces the number of macrophages in bronchoalveolar lavage fluid (BALF) in a mouse model of infection with influenza H1N1 A/PR/8/34 when administered at a dose of 6 mg/kg[1]
Animal Research	In vivo, female BALB/c mice were infected intranasally with 150 pfu of influenza H1N1 A/Puerto Rico/8/34 and treated with Acumapimod(BCT197) (a closely related p38 MAPK inhibitor with an IC50 value of<1?μM, currently in clinical testing), dexamethasone or oseltamivir (Tamiflu) starting 24?h post infection. Body weight, bronchoalveolar lavage cells, cytokines, total protein and lactate dehydrogenase as well as serum cytokines were measured; a subset of animals was evaluated histopathologically[1].

Synonyms	BCT-197
Molecular Weight	385.42
Formula	C22H19N5O2
CAS No.	836683-15-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (129.73 mM)

References and Literature

1. Growcott E J , Bamba D , Galarneau J . R , et al. The effect of P38 MAP kinase inhibition in a mouse model of influenza[J]. Journal of Medical Microbiology, 2018, 67(3). 2. De Buck S , Hueber W , Vitaliti A , et al. Population PK-PD Model for Tolerance Evaluation to the p38 MAP Kinase Inhibitor BCT197[J]. CPT: Pharmacometrics & Systems Pharmacology, 2015, 4(12):691-700.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Bioactive Compounds Library Max ReFRAME Related Library Anti-Prostate Cancer Compound Library MAPK Inhibitor Library Neural Regeneration Compound Library Anti-Ovarian Cancer Compound Library Anti-Liver Cancer Compound Library Pyroptosis Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Acumapimod 836683-15-9 Autophagy MAPK p38 MAPK inhibit BCT197 Inhibitor BCT-197 BCT 197 inhibitor

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