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Ataciguat

Catalog No. T21607 CAS 254877-67-3

Synonyms: HMR-1766

Ataciguat (HMR-1766) is a potent and specific soluble guanylate cyclase (sGC) activator.

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Ataciguat, CAS 254877-67-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ataciguat (HMR-1766) is a potent and specific soluble guanylate cyclase (sGC) activator.
In vitro	Ataciguat induces the relaxation in aortic rings or coronary rings. In the presence of nitric oxide synthase (NOS) inhibitor, the endothelium effect was abolished to DETA-NO or ataciguat, in both vessels. Ataciguat was able to induce NO production in HUVECs cells. In the presence of NOS inhibitor, the NO production induced by ataciguat was abolished[1].

Synonyms	HMR-1766
Molecular Weight	576.48
Formula	C21H19Cl2N3O6S3
CAS No.	254877-67-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 95mg/mL (164.79 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Martinelli AM, et, al. In Endothelial Cells, the Activation or Stimulation of Soluble Guanylyl Cyclase Induces the Nitric Oxide Production by a Mechanism Dependent of Nitric Oxide Synthase Activation. J Pharm Pharm Sci. 2018;21(1):38-45.

Related Products

Related compounds with same targets

Plecanatide Nelociguat Nitroprusside disodium dihydrate Methylene Blue MCUF-651 LY83583 ODQ Runcaciguat

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ataciguat 254877-67-3 G蛋白偶联受体其他 Guanylate cyclase Others cyclase soluble HMR 1766 Guanylate Cyclase Inhibitor sGC HMR-1766 inhibit HMR1766 vasodilator cGMP guanylate inhibitor

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