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Search Result

Search Results for " cyclase "

Targets

Guanylate cyclase Adenylyl cyclase Guanylate cyclase

140

Compounds

6

Natural Products

72

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T11424 Glutaminyl Cyclase Inhibitor 1 Guanylate cyclase
Glutaminyl Cyclase Inhibitor 1 is a glutaminyl cyclase inhibitor (IC50: 0.5 μM) that can be used to study neurological disorders.
T38770 Guanylate cyclase-IN-1
Guanylate cyclase-IN-1 (Example 46) is a specific inhibitor of guanylate cyclase, employed in research related to cardiovascular diseases.
T16333 NKY80 Adenylyl cyclase type V Inhibitor Adenylyl cyclase
NKY80 regulates the adenylyl cyclase catalytic activity in heart and lung tissues. NKY80 is a non-competitive inhibitor of adenylyl cyclase type V isoform (IC50s: 8.3 µM, 132 µM, and 1.7 mM for type V, III and II, respe...
T11423 Glutaminyl Cyclase Inhibitor 4 Others
Glutaminyl Cyclase Inhibitor 4 is a potent, selective glutaminyl cyclase (QC) inhibitor (IC50: 6.1 nM). It is a potent anti-Alzheimer’s agent.
T11425 Glutaminyl Cyclase Inhibitor 2 Others
Glutaminyl Cyclase Inhibitor 2 is a glutaminyl cyclase inhibitor (IC50: 1.23 μM).
T11422 Glutaminyl Cyclase Inhibitor 3 Others
Glutaminyl Cyclase Inhibitor 3, a designed anti-Alzheimer’s compound, is a potent human Glutaminyl Cyclase (GC) inhibitor (IC50: 4.5 nM). It significantly reduced the brain concentrations of pyroform Aβ and total Aβ and ...
T72136 Glutaminyl Cyclase Inhibitor 5
Glutaminyl Cyclase Inhibitor 5 is a potent, selective inhibitor of human glutaminyl cyclase (hQC), demonstrating an inhibition concentration half-max (IC 50) of 3.2 nM.
T83169 Adenylyl cyclase-IN-1
Adenylyl cyclase-IN-1 is a potential adenylyl cyclase inhibitor for ocular hypotonia research [1].
T63893 Adenylyl cyclase type 2 agonist-1
Adenylyl cyclase type 2 agonist-1 is a potent agonist of adenylyl cyclase type 2 (AC2) (EC50: 90 nM). It is a potential lead compound in the fight against respiratory diseases.
T15658 KH7 cAMP , AChR
KH7 is a soluble inhibitor of adenylyl cyclase (sAC)-specific. It has IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays. KH7 is also a cAMP inhibito...
T9080 Plecanatide Guanylate cyclase
Plecanatide acetate is an analogue of Uroguanylin. It is an orally active guanylate cyclase-C (GC-C) receptor agonist.
T10066 2',5'-Dideoxyadenosine Adenylyl cyclase , Adrenergic Receptor , AChR
2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site (IC50: 3 μM).
T16938 ST034307 Adenylyl cyclase
ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM).
T16808 Runcaciguat Others , Guanylate cyclase
Runcaciguat is a soluble guanylate cyclase stimulator. Runcaciguat combines with selective partial adenosine A1 receptor agonists and can be used in studies about cardiovascular and renal diseases.
T11852 Linaclotide Guanylate cyclase
Linaclotide developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, and is a potent and selective guanylate cyclase C agonist.
T60003 AC1-IN-1 Adenylyl cyclase
AC1-IN-1 is a selective inhibitor of adenylyl cyclase type 1 (AC1, IC50 = 0.54 µM).
T0322 Fipexide Dopamine Receptor , AChR
Fipexide (Attentil, Vigilor), a psychoactive drug of the piperazine chemical class, was developed in Italy in 1983. It was served as a nootropic drug in France and Italy, mainly for the therapy of senile dementia, but is...
T21607 Ataciguat HMR-1766 Others , Guanylate cyclase
Ataciguat (HMR-1766) (HMR-1766) is a potent and specific soluble guanylate cyclase (sGC) activator.
T80069 PACAP (6-27) (human, ovine, rat) Pituitary adenylate cyclase-activating peptide (6-27)
PACAP (6-27) (human, ovine, rat) serves as an antagonist for the PACAP receptor, inhibiting the catecholamine response of the canine adrenal gland to vasoactive intestinal peptide (VIP). This compound holds promise for r...
T16275 NB001 HTS 09836 Adenylyl cyclase
NB001 (HTS 09836) is an inhibitor of adenyl cyclase 1 exhibiting effects on neural and non-neural pain.
T19777 ODQ Apoptosis , Others , Guanylate cyclase
ODQ is an effective and selective soluble guanylyl cyclase (sGC) inhibitor.
T6775 BAY 41-2272 Guanylate cyclase
BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.
T16344 NS-2028 Others , Guanylate cyclase
NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity). It is commonly used in the research of nitric oxide signaling pathways. NS-2028...
T1984 Cinaciguat BAY 58-2667 Guanylate cyclase
Cinaciguat (BAY 58-2667) (BAY 58-2667) is the first of a new class of soluble guanylate cyclase (sGC) activators in Clinicalal development for acute decompensated heart failure.
TP1054 PACAP (1-38), human, ovine, rat TFA Pituitary Adenylate Cyclase Activating Polypeptide 38 (TFA)
PACAP (1-38), a novel neuropeptide isolated from the bovine hypothalamus is more active than vasoactive intestinal peptide (VIP) in stimulating adenylate cyclase (EC50=7 nM). PACAP 1-38 (10-9 M) increased substance P (SP...
TP1878 PACAP (1-38), human, ovine, rat Pituitary Adenylate Cyclase Activating Polypeptide 38,PACAP 1-38 PACAP
PACAP (1-38), human, ovine, rat (Pituitary Adenylate Cyclase Activating Polypeptide 38) is a neuropeptide with 38 amino acid residues.
T16569 Praliciguat IW-1973 Others , Guanylate cyclase
Praliciguat (IW-1973) stimulates sGC in HEK-293 cells (EC50: 197 nM). Praliciguat is an effective and orally active soluble guanylate cyclase stimulator. It also enhances NO signaling and acts as a vasodilator.
T8702 SKF-83566 Dopamine Receptor , 5-HT Receptor , AChR
SKF-83566 is a blood-brain permeable and orally active antagonist of D1-like dopamine receptor and a weaker competitive 5-HT2 receptor antagonist with Ki of 11 nM
T16383 Olinciguat IW-1701 Guanylate cyclase
Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator. It also has concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole-cell assay.
T2172 SQ22536 9-(tetrahydrofuran-2-yl)-9h-purin-6-amine,SQ 22536 AChR
SQ22536 (9-(tetrahydrofuran-2-yl)-9h-purin-6-amine) , the adenosine analogue 9-(Tetrahydro-2-furyl)adenine, inhibited adenylate cyclase activity of crude membrane preparations from catfish (Ictalurus melas) and rat isola...
T4039 BIBB 515 Others
BIBB 515 is a selective and potent inhibitor of OSC in vivo with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. 2, 3-Oxidosqualene cyclase (OSC) is an important enzyme in the biosynthesis of...
T17226 Vericiguat BAY1021189 Guanylate cyclase
Vericiguat (BAY1021189) is a potent and orally available guanylate cyclase stimulator.
T6968 Riociguat BAY 632521 Guanylate cyclase
Riociguat (BAY 632521) is a stimulator of guanylate cyclase which causes relaxation of vascular smooth muscle and is used to treat severe pulmonary arterial hypertension.
T4381 Lificiguat YC-1 Others , Guanylate cyclase , HIF
Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).
T26869 BMS-986122 BMS 986122 Opioid Receptor
BMS-986122 (BMS 986122) is a positive allosteric modulator of μ-opioid receptors that increases β-arrestin recruitment stimulated by endomorphin 1 in U2OS-OPRM1 human osteosarcoma cells expressing μ-opioid receptors (EC5...
T21712 BAY 41-8543 Others , Guanylate cyclase
BAY 41-8543 is a nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC).
T0830 Bithionol Actamer cAMP , Parasite
Bithionol (Actamer), formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause serious skin disorders. Approvals of the NDA's for bit...
T12670 (Rac)-MGV354 MGV354 Others
(Rac)-MGV354 (MGV354) is the racemate of MGV354. MGV354 is a soluble activator of guanylate cyclase (sGC)(EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively).
T7201 Nelociguat BAY60-4552 Guanylate cyclase
Nelociguat (BAY60-4552)(BAY60-4552) is a soluble guanylate cyclase stimulator (sGC stimulator). Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signalling pathway.
T11918 Lysipressin Lysine vasopressin,[Lys8]-Vasopressin Others
Lysipressin ([Lys8]-Vasopressin), Induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase. Lysipressin is Antidiuretic hormone that have been found in pigs and some marsupial families.
T6888 Methylene Blue methylthioninium chloride,CI-52015,Tetramethylthionine chloride,Basic Blue 9 Guanylate cyclase , Microtubule Associated , NO Synthase , Parasite , Monoamine Oxidase
Methylene Blue (Tetramethylthionine chloride) (IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
T0006 Methylene Blue trihydrate Methylthionine chloride,Basic blue 9,Methylene Blue Guanylate cyclase , Microtubule Associated , NO Synthase , Parasite , Monoamine Oxidase
Methylene Blue trihydrate (Basic blue 9) is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene Blue trihydrate...
T63139 Glutaminyl cyclases-IN-1
Glutaminyl cyclases-IN-1 (IsoQC-IN-1) is a potent inhibitor of Glutaminyl cyclases (QC), which acts on human QC (IC50: 12 nM) and isoQC (IC 50:73 nM). Glutaminyl cyclases-IN-1 inhibited isoQC and selectively blocked CD47...
T21576 LY83583 6-Anilino-5,8-quinolinedione,6-anilinoquinoline-5,8-dione Guanylate cyclase
LY83583 is a soluble guanylate cyclase competitive inhibitor with IC50 of 2 µM.
T14880 CB-7921220 6-[2-(4-Aminophenyl)vinyl]-2-pyridinecarboxylic acid,6-(4-Aminostyryl)picolinic acid,6-[(E)-2-(4-aminophenyl)ethenyl]pyridine-2-carboxylic acid AChR
CB-7921220 (6-[2-(4-Aminophenyl)vinyl]-2-pyridinecarboxylic acid) is an inhibitor of adenylate cyclase.
T15787 LRE1 Adenylyl cyclase
LRE1 is a specific and allosteric soluble adenylyl cyclase inhibitor.
T67734 MCUF-651 Guanylate cyclase
MCUF-651 is a guanylyl cyclase A receptor positive allosteric modulators, EC50=0.45 μM.
T23588 9-CP-Ade Mesylate 9-Cyclopentyladenine monomethanesulfonate,9 CP Ade Mesylate,9CPAde Mesylate AChR
9-CP-Ade Mesylate (9 CP Ade Mesylate) is a cell-permeable, stable and non-competitive inhibitor of adenylate cyclase.
T76769 Indusatumab Guanylate cyclase
Indusatumab (5F9 Monoclonal antibody) is an anti-human GUCY2C (Guanylate cyclase 2C) monoclonal antibody that can be used to synthesize antibody-drug conjugate.
T1771 Ro 48-8071 fumarate Others
Ro 48-8071 fumarate is an inhibitor of OSC(Oxidosqualene cyclase; IC50=6.5 nM) that has low-density lipoprotein (LDL) cholesterol lowering activity.

Compounds

Glutaminyl Cyclase Inhibitor 1
T11424
Synonym:
Target: Guanylate cyclase
Guanylate cyclase-IN-1
T38770
Synonym:
Target:
NKY80
T16333
Synonym: Adenylyl cyclase type V Inhibitor
Target: Adenylyl cyclase
Glutaminyl Cyclase Inhibitor 4
T11423
Synonym:
Target: Others
Glutaminyl Cyclase Inhibitor 2
T11425
Synonym:
Target: Others
Glutaminyl Cyclase Inhibitor 3
T11422
Synonym:
Target: Others
Glutaminyl Cyclase Inhibitor 5
T72136
Synonym:
Target:
Adenylyl cyclase-IN-1
T83169
Synonym:
Target:
Adenylyl cyclase type 2 agonist-1
T63893
Synonym:
Target:
KH7
T15658
Synonym:
Target: cAMP, AChR
Plecanatide
T9080
Synonym:
Target: Guanylate cyclase
2',5'-Dideoxyadenosine
T10066
Synonym:
Target: Adenylyl cyclase, Adrenergic Receptor, AChR
ST034307
T16938
Synonym:
Target: Adenylyl cyclase
Runcaciguat
T16808
Synonym:
Target: Others, Guanylate cyclase
Linaclotide
T11852
Synonym:
Target: Guanylate cyclase
AC1-IN-1
T60003
Synonym:
Target: Adenylyl cyclase
Fipexide
T0322
Synonym:
Target: Dopamine Receptor, AChR
Ataciguat
T21607
Synonym: HMR-1766
Target: Others, Guanylate cyclase
PACAP (6-27) (human, ovine, rat)
T80069
Synonym: Pituitary adenylate cyclase-activating peptide (6-27)
Target:
NB001
T16275
Synonym: HTS 09836
Target: Adenylyl cyclase
ODQ
T19777
Synonym:
Target: Apoptosis, Others, Guanylate cyclase
BAY 41-2272
T6775
Synonym:
Target: Guanylate cyclase
NS-2028
T16344
Synonym:
Target: Others, Guanylate cyclase
Cinaciguat
T1984
Synonym: BAY 58-2667
Target: Guanylate cyclase
PACAP (1-38), human, ovine, rat TFA
TP1054
Synonym: Pituitary Adenylate Cyclase Activating Polypeptide 38 (TFA)
Target:
PACAP (1-38), human, ovine, rat
TP1878
Synonym: Pituitary Adenylate Cyclase Activating Polypeptide 38,PACAP 1-38
Target: PACAP
Praliciguat
T16569
Synonym: IW-1973
Target: Others, Guanylate cyclase
SKF-83566
T8702
Synonym:
Target: Dopamine Receptor, 5-HT Receptor, AChR
Olinciguat
T16383
Synonym: IW-1701
Target: Guanylate cyclase
SQ22536
T2172
Synonym: 9-(tetrahydrofuran-2-yl)-9h-purin-6-amine,SQ 22536
Target: AChR
BIBB 515
T4039
Synonym:
Target: Others
Vericiguat
T17226
Synonym: BAY1021189
Target: Guanylate cyclase
Riociguat
T6968
Synonym: BAY 632521
Target: Guanylate cyclase
Lificiguat
T4381
Synonym: YC-1
Target: Others, Guanylate cyclase, HIF
BMS-986122
T26869
Synonym: BMS 986122
Target: Opioid Receptor
BAY 41-8543
T21712
Synonym:
Target: Others, Guanylate cyclase
Bithionol
T0830
Synonym: Actamer
Target: cAMP, Parasite
(Rac)-MGV354
T12670
Synonym: MGV354
Target: Others
Nelociguat
T7201
Synonym: BAY60-4552
Target: Guanylate cyclase
Lysipressin
T11918
Synonym: Lysine vasopressin,[Lys8]-Vasopressin
Target: Others
Methylene Blue
T6888
Synonym: methylthioninium chloride,CI-52015,Tetramethylthionine chloride,Basic Blue 9
Target: Guanylate cyclase, Microtubule Associated, NO Synthase, Parasite, Monoamine Oxidase
Methylene Blue trihydrate
T0006
Synonym: Methylthionine chloride,Basic blue 9,Methylene Blue
Target: Guanylate cyclase, Microtubule Associated, NO Synthase, Parasite, Monoamine Oxidase
Glutaminyl cyclases-IN-1
T63139
Synonym:
Target:
LY83583
T21576
Synonym: 6-Anilino-5,8-quinolinedione,6-anilinoquinoline-5,8-dione
Target: Guanylate cyclase
CB-7921220
T14880
Synonym: 6-[2-(4-Aminophenyl)vinyl]-2-pyridinecarboxylic acid,6-(4-Aminostyryl)picolinic acid,6-[(E)-2-(4-aminophenyl)ethenyl]pyridine-2-carboxylic acid
Target: AChR
LRE1
T15787
Synonym:
Target: Adenylyl cyclase
MCUF-651
T67734
Synonym:
Target: Guanylate cyclase
9-CP-Ade Mesylate
T23588
Synonym: 9-Cyclopentyladenine monomethanesulfonate,9 CP Ade Mesylate,9CPAde Mesylate
Target: AChR
Indusatumab
T76769
Synonym:
Target: Guanylate cyclase
Ro 48-8071 fumarate
T1771
Synonym:
Target: Others
1 2 3
Cat No. Product Name Synonyms Targets
T2939 Forskolin Coleonol,Colforsin FXR , Adenylyl cyclase , AChR , Autophagy
Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces autophagy. Forskolin produces positive inotropic effects in the...
T1723 Adenosine 5'-diphosphate Adenosine diphosphate,adenosine pyrophosphate,ADP Endogenous Metabolite
Adenosine 5'-diphosphate (ADP) induces human platelet aggregation and non-competitively blocks the stimulated human platelet adenylate cyclase.
T1626 Prostaglandin E1 PGE1,Alprostadil Endogenous Metabolite , Prostaglandin Receptor
Prostaglandin E1 (Alprostadil) is the naturally occurring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Prostaglandin E1 is a potent vasodilator agent that increases peripheral blood flow, in...
T19253 Cyclic ADP-​ribose cADPR Calcium Channel
Cyclic ADP-ribose (cADPR) is an effective calcium mobilization second messenger, which is synthesized from NAD + by ADP-ribosyl cyclase. Cyclic ADP-ribose mainly increases cytosolic calcium through Ryanodine receptor-med...
T37687 Cyclic ADP-ribose ammonium
Cyclic ADP-ribose ammonium (cADPR ammonium) is a powerful calcium mobilization second messenger synthesized from NAD+ by an ADP-ribosyl cyclase. It primarily raises cytosolic calcium levels through Ryanodine receptor-med...
T16332 NKH477 Colforsin dapropate hydrochloride NMDAR
NKH477 is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 shows an antiproliferative effect in vivo with an altered cyt...

Natural Products

Forskolin
T2939
Synonym: Coleonol,Colforsin
Target: FXR, Adenylyl cyclase, AChR, Autophagy
Adenosine 5'-diphosphate
T1723
Synonym: Adenosine diphosphate,adenosine pyrophosphate,ADP
Target: Endogenous Metabolite
Prostaglandin E1
T1626
Synonym: PGE1,Alprostadil
Target: Endogenous Metabolite, Prostaglandin Receptor
Cyclic ADP-​ribose
T19253
Synonym: cADPR
Target: Calcium Channel
Cyclic ADP-ribose ammonium
T37687
Synonym:
Target:
NKH477
T16332
Synonym: Colforsin dapropate hydrochloride
Target: NMDAR

Recombinant Proteins

Species：
Human (39)
Mouse (11)
E. coli (7)
Rat (7)
Cynomolgus,Rhesus (2)
Canine (1)
Cynomolgus (1)
Mycobacterium paratuberculosis (1)
Rabbit (1)
Sus scrofa (Pig) (1)
Expression System：
HEK293 (32)
E. coli (27)
in vitro E. coli expression system (6)
Human Cells (4)
Baculovirus-Insect Cells (3)
Tag：
His (13)
N-terminal 6xHis-tagged (9)
N-terminal 10xHis-tagged and C-terminal Myc-tagged (8)
N-terminal 10xHis-tagged (5)
hFc (5)
N-terminal 6xHis-SUMO-tagged (4)
C-Fc (3)
C-His-Avi (3)
Tag Free (3)
C-His (2)
Cat No. Product Name Species Expression System
TMPH-00574 Adenylate cyclase Protein, E. coli, Recombinant (His) E. coli in vitro E. coli expression system
Catalyzes the formation of the second messenger cAMP from ATP. Its transcript is probably degraded by endoribonuclease LS (rnlA), decreasing cAMP levels and the negative regulator Crp-cAMP, which then induces its own tra...
TMPJ-00911 GUCY2C Protein, Human, Recombinant (hFc) Human Human Cells
GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family. GUCY2C cell surface expression is confined to luminal surfaces of the i...
TMPJ-00910 GUCY2C Protein, Human, Recombinant (His & Avi), Biotinylated Human Human Cells
GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family. GUCY2C cell surface expression is confined to luminal surfaces of the i...
TMPY-06353 GUCA2B Protein, Mouse, Recombinant (His) Mouse HEK293
TMPJ-00190 CD38 Protein, Mouse, Recombinant (hFc) Mouse Human Cells
CD38, also called ADP-ribosyl cyclase, is a Type II integral membrane protein with 301 amino acids in length that belongs to the ADP-ribosyl cyclase family.It synthesizes the second messagers cyclic ADP-ribose and nicoti...
TMPJ-00202 CD157 Protein, Human, Recombinant (hFc) Human Human Cells
The cluster of differentiation (CD) system is a glycosyl phosphatidylinositol anchored membrane protein that belongs to the CD38 family.It is generally used in immunophynotyping. CD157 was discovered in a bone marrow str...
TMPY-02648 PACAP receptor/ADCYAP1R1 Protein, Human, Recombinant (hFc) Human HEK293
Pituitary adenylate cyclase activating polypeptide (PACAP, Adcyap1) activation of PAC1 receptors ( Adcyap1r1) significantly increases excitability of guinea pig cardiac neurons. This modulation of excitability is mediate...
TMPY-03554 GCAP1 Protein, Human, Recombinant Human Baculovirus-Insect Cells
GCAP 1 gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messenger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by ...
TMPY-03463 GCAP1 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
GCAP 1 gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messenger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by ...
TMPK-01279 GUCY2C Protein, Cynomolgus, Recombinant (aa 24-430, His) Cynomolgus HEK293
Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier functio...
TMPH-02993 DisA Protein, Mycobacterium paratuberculosis, Recombinant (His & Myc) Mycobacterium paratuberculosis E. coli
Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules int...
TMPK-00856 GUCY2C Protein, Human, Recombinant (His & Avi) Human HEK293
Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier functio...
TMPK-01388 GUCY2C Protein, Canine, Recombinant (aa 21-430, His) Canine HEK293
Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier functio...
TMPK-00991 GUCY2C Protein, Mouse, Recombinant (His & Avi), Biotinylated Mouse HEK293
Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier functio...
TMPK-00990 GUCY2C Protein, Mouse, Recombinant (His & Avi) Mouse HEK293
Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier functio...
TMPY-01023 CD38 Protein, Human, Recombinant (His) Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-05573 CD38 Protein, Human, Recombinant (His), PE conjugated Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-03923 CD38 Protein, Cynomolgus, Rhesus, Recombinant (His) Cynomolgus,Rhesus HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPH-02693 GNAI2 Protein, Mouse, Recombinant (His) Mouse E. coli
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhi...
TMPH-00862 HTR1F Protein, Human, Recombinant (His & SUMO) Human in vitro E. coli expression system
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guan...
TMPH-01715 CHRM2 Protein, Human, Recombinant (His) Human E. coli
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. ...
TMPH-00631 Heat-labile enterotoxin B chain Protein, E. coli, Recombinant (His) E. coli E. coli
The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.
TMPH-00892 A1AR Protein, Human, Recombinant (His) Human in vitro E. coli expression system
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
TMPH-01618 LHCGR Protein, Human, Recombinant (His) Human E. coli
Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
TMPH-02672 GIPR Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
TMPH-01386 GLP2R Protein, Human, Recombinant (His) Human HEK293
This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
TMPH-03132 AVPR2 Protein, Pig, Recombinant (His & SUMO) Sus scrofa (Pig) E. coli
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption.
TMPH-00632 Heat-labile enterotoxin B chain Protein, E. coli, Recombinant (His & Myc) E. coli E. coli
The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.
TMPH-00630 Heat-labile enterotoxin A chain Protein, E. coli, Recombinant (His & Myc) E. coli E. coli
The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.
TMPH-00633 Heat-stable enterotoxin A2 Protein, E. coli, Recombinant (His & Myc & SUMO) E. coli E. coli
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells.
TMPH-01378 GIPR Protein, Human, Recombinant (His & Myc) Human HEK293
This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
TMPH-01377 GIPR Protein, Human, Recombinant (His) Human E. coli
This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
TMPH-00634 Heat-stable enterotoxin ST-2 Protein, E. coli, Recombinant E. coli E. coli
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells.
TMPH-00635 Heat-stable enterotoxin ST-IA/ST-P Protein, E. coli, Recombinant (GST) E. coli E. coli
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells.
TMPH-00861 HTR1D Protein, Human, Recombinant (His & KSI) Human E. coli
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding c...
TMPH-01382 GCGR Protein, Human, Recombinant (E. coli, His & Myc) Human E. coli
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and g...
TMPH-02675 GCGR Protein, Mouse, Recombinant (GST) Mouse E. coli
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and g...
TMPH-01714 CHRM1 Protein, Human, Recombinant (His) Human E. coli
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. ...
TMPH-03715 Y-STB Protein, Yersinia enterocolitica, Recombinant (His & SUMO) Yersinia enterocolitica E. coli
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells. Could play an important role in pathogenesis.
TMPY-03260 QPCT Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Glutaminyl cyclase, also known as QPCT, can promote the N-terminal cyclization reaction of N-terminal pyroglutamate(pGlu). The pGlu formation from its glutaminyl precursor is required in the maturation of numerous bioact...
TMPH-01201 DRD2 Protein, Human, Recombinant (His & Myc) Human E. coli
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5.
TMPH-01385 GLP1R Protein, Human, Recombinant (His) Human HEK293
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a ...
TMPH-01384 GLP1R Protein, Human, Recombinant (E. coli, His) Human E. coli
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a ...
TMPH-01716 CHRM3 Protein, Human, Recombinant (B2M & His) Human E. coli
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. ...
TMPH-01717 CHRM5 Protein, Human, Recombinant (His) Human E. coli
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. ...
TMPH-01383 GCGR Protein, Human, Recombinant (His & Myc) Human HEK293
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and g...
TMPH-00860 HTR1D Protein, Human, Recombinant (hFc) Human HEK293
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding c...
TMPH-00859 HTR1B Protein, Human, Recombinant (His) Human in vitro E. coli expression system
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic...
TMPH-03301 GLP1R Protein, Rat, Recombinant (E. coli, His) Rat E. coli
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a ...
TMPH-02676 GLP1R Protein, Mouse, Recombinant (His & SUMO) Mouse E. coli
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a ...
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Adenylate cyclase Protein, E. coli, Recombinant (His)
TMPH-00574
Species: E. coli
Expression System: in vitro E. coli expression system
GUCY2C Protein, Human, Recombinant (hFc)
TMPJ-00911
Species: Human
Expression System: Human Cells
GUCY2C Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00910
Species: Human
Expression System: Human Cells
GUCA2B Protein, Mouse, Recombinant (His)
TMPY-06353
Species: Mouse
Expression System: HEK293
CD38 Protein, Mouse, Recombinant (hFc)
TMPJ-00190
Species: Mouse
Expression System: Human Cells
CD157 Protein, Human, Recombinant (hFc)
TMPJ-00202
Species: Human
Expression System: Human Cells
PACAP receptor/ADCYAP1R1 Protein, Human, Recombinant (hFc)
TMPY-02648
Species: Human
Expression System: HEK293
GCAP1 Protein, Human, Recombinant
TMPY-03554
Species: Human
Expression System: Baculovirus-Insect Cells
GCAP1 Protein, Human, Recombinant (His & GST)
TMPY-03463
Species: Human
Expression System: Baculovirus-Insect Cells
GUCY2C Protein, Cynomolgus, Recombinant (aa 24-430, His)
TMPK-01279
Species: Cynomolgus
Expression System: HEK293
DisA Protein, Mycobacterium paratuberculosis, Recombinant (His & Myc)
TMPH-02993
Species: Mycobacterium paratuberculosis
Expression System: E. coli
GUCY2C Protein, Human, Recombinant (His & Avi)
TMPK-00856
Species: Human
Expression System: HEK293
GUCY2C Protein, Canine, Recombinant (aa 21-430, His)
TMPK-01388
Species: Canine
Expression System: HEK293
GUCY2C Protein, Mouse, Recombinant (His & Avi), Biotinylated
TMPK-00991
Species: Mouse
Expression System: HEK293
GUCY2C Protein, Mouse, Recombinant (His & Avi)
TMPK-00990
Species: Mouse
Expression System: HEK293
CD38 Protein, Human, Recombinant (His)
TMPY-01023
Species: Human
Expression System: HEK293
CD38 Protein, Human, Recombinant (His), PE conjugated
TMPY-05573
Species: Human
Expression System: HEK293
CD38 Protein, Cynomolgus, Rhesus, Recombinant (His)
TMPY-03923
Species: Cynomolgus,Rhesus
Expression System: HEK293
GNAI2 Protein, Mouse, Recombinant (His)
TMPH-02693
Species: Mouse
Expression System: E. coli
HTR1F Protein, Human, Recombinant (His & SUMO)
TMPH-00862
Species: Human
Expression System: in vitro E. coli expression system
CHRM2 Protein, Human, Recombinant (His)
TMPH-01715
Species: Human
Expression System: E. coli
Heat-labile enterotoxin B chain Protein, E. coli, Recombinant (His)
TMPH-00631
Species: E. coli
Expression System: E. coli
A1AR Protein, Human, Recombinant (His)
TMPH-00892
Species: Human
Expression System: in vitro E. coli expression system
LHCGR Protein, Human, Recombinant (His)
TMPH-01618
Species: Human
Expression System: E. coli
GIPR Protein, Mouse, Recombinant (His & Myc)
TMPH-02672
Species: Mouse
Expression System: E. coli
GLP2R Protein, Human, Recombinant (His)
TMPH-01386
Species: Human
Expression System: HEK293
AVPR2 Protein, Pig, Recombinant (His & SUMO)
TMPH-03132
Species: Sus scrofa (Pig)
Expression System: E. coli
Heat-labile enterotoxin B chain Protein, E. coli, Recombinant (His & Myc)
TMPH-00632
Species: E. coli
Expression System: E. coli
Heat-labile enterotoxin A chain Protein, E. coli, Recombinant (His & Myc)
TMPH-00630
Species: E. coli
Expression System: E. coli
Heat-stable enterotoxin A2 Protein, E. coli, Recombinant (His & Myc & SUMO)
TMPH-00633
Species: E. coli
Expression System: E. coli
GIPR Protein, Human, Recombinant (His & Myc)
TMPH-01378
Species: Human
Expression System: HEK293
GIPR Protein, Human, Recombinant (His)
TMPH-01377
Species: Human
Expression System: E. coli
Heat-stable enterotoxin ST-2 Protein, E. coli, Recombinant
TMPH-00634
Species: E. coli
Expression System: E. coli
Heat-stable enterotoxin ST-IA/ST-P Protein, E. coli, Recombinant (GST)
TMPH-00635
Species: E. coli
Expression System: E. coli
HTR1D Protein, Human, Recombinant (His & KSI)
TMPH-00861
Species: Human
Expression System: E. coli
GCGR Protein, Human, Recombinant (E. coli, His & Myc)
TMPH-01382
Species: Human
Expression System: E. coli
GCGR Protein, Mouse, Recombinant (GST)
TMPH-02675
Species: Mouse
Expression System: E. coli
CHRM1 Protein, Human, Recombinant (His)
TMPH-01714
Species: Human
Expression System: E. coli
Y-STB Protein, Yersinia enterocolitica, Recombinant (His & SUMO)
TMPH-03715
Species: Yersinia enterocolitica
Expression System: E. coli
QPCT Protein, Human, Recombinant (His)
TMPY-03260
Species: Human
Expression System: Baculovirus-Insect Cells
DRD2 Protein, Human, Recombinant (His & Myc)
TMPH-01201
Species: Human
Expression System: E. coli
GLP1R Protein, Human, Recombinant (His)
TMPH-01385
Species: Human
Expression System: HEK293
GLP1R Protein, Human, Recombinant (E. coli, His)
TMPH-01384
Species: Human
Expression System: E. coli
CHRM3 Protein, Human, Recombinant (B2M & His)
TMPH-01716
Species: Human
Expression System: E. coli
CHRM5 Protein, Human, Recombinant (His)
TMPH-01717
Species: Human
Expression System: E. coli
GCGR Protein, Human, Recombinant (His & Myc)
TMPH-01383
Species: Human
Expression System: HEK293
HTR1D Protein, Human, Recombinant (hFc)
TMPH-00860
Species: Human
Expression System: HEK293
HTR1B Protein, Human, Recombinant (His)
TMPH-00859
Species: Human
Expression System: in vitro E. coli expression system
GLP1R Protein, Rat, Recombinant (E. coli, His)
TMPH-03301
Species: Rat
Expression System: E. coli
GLP1R Protein, Mouse, Recombinant (His & SUMO)
TMPH-02676
Species: Mouse
Expression System: E. coli
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