Home Tools
Log in
Cart

BAY 11-7082

Catalog No. T1902   CAS 19542-67-7
Synonyms: BAY 11-7821

BAY 11-7082, a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
BAY 11-7082 Chemical Structure
BAY 11-7082, CAS 19542-67-7
Pack Size Availability Price/USD Quantity
5 mg In stock $ 43.00
10 mg In stock $ 52.00
25 mg In stock $ 97.00
50 mg In stock $ 173.00
100 mg In stock $ 279.00
200 mg In stock $ 419.00
500 mg In stock $ 697.00
1 mL * 10 mM (in DMSO) In stock $ 48.00
Bulk Inquiry
Get quote
Select Batch  
Purity: 99.92%
Purity: 99.83%
Purity: 98%
Purity: 97.91%
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description BAY 11-7082, a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21.
Targets&IC50 IκBα phosphorylation:10 μM
Kinase Assay UBE1 (0.17 μM) in 22.5 μL of 20 mM Hepes, pH 7.5, containing 10 μM ubiquitin is incubated for 45 min at 21°C with 1 μL of DMSO or 1 μL of BAY 11-7082 in DMSO. A 2.5 μL solution of 10 mM magnesium acetate and 0.2 mM ATP is added, incubated for 10 min at 30°C, and the reactions are terminated by the addition of 2.5 μL of 10% (w/v) SDS and heating for 6 min at 75°C. The samples are subjected to SDS/PAGE in the absence of any thiol. The gels are stained for 1 h with Coomassie Instant Blue and destained by washing with water. The loading of ubiquitin to E2 conjugating enzymes is carried out in an identical manner, except that UBE1 (0.17 μM) is mixed with Ubc13 (2.4 μM) or UbcH7 (2.9 μM) prior to incubation with BAY 11-7082[3].
Cell Research Cells are transfected with siRNA in 96-well microtiter plates and then cultured for 72 hours in complete NSCLC medium, treated with BAY 11-7082 for 12 hours. Cells are incubated with [3H]thymidine for 3 hours. The cells are collected on filters using an automatic cell harvester and radioactivity on the filters is measured by β-scintillation counting.(Only for Reference)
Synonyms BAY 11-7821
Molecular Weight 207.25
Formula C10H9NO2S
CAS No. 19542-67-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 5.2 mg/mL (25 mM)

DMSO: 20.7 mg/mL (100 mM)

TargetMolReferences and Literature

1. Melisi D, et al. Expert Opin Ther Targets, 2007, 11(2), 133-144. 2. Gastonguay A, et al. Cancer Biol Ther, 2012, 13(8), 647-656. 3. Miwatashi S, et al. J Med Chem, 2005, 48(19), 5966-5979. 4. Mori N, et al. Blood, 2002, 100(5), 1828-1834. 5. Goffi F, et al. Neurosci Lett, 2005, 377(3), 147-151. 6. Jun Jacob Hu, et al. Identification of pyroptosis inhibitors that target a reactive cysteine in gasdermin D. The Preprint Server For Biology, 2018,Jul. 10. 7. Shen S C, He F, Cheng C, et al. Uric acid aggravates myocardial ischemia–reperfusion injury via ROS/NLRP3 pyroptosis pathway[J]. Biomedicine & Pharmacotherapy . 2020, 133: 110990. 8. Yu Y, Li Z, Guo R, et al. Ononin, sec-O-β-D-glucosylhamaudol and astragaloside I: antiviral lead compounds identified via high throughput screening and biological validation from traditional Chinese medicine Zhongjing formulary[J]. Pharmacological Research. 2019 May 11;145:104248. 10. Gao J, Wang Y, Zhang W, et al. C20orf27 Promotes Cell Growth and Proliferation of Colorectal Cancer via the TGFβR-TAK1-NFĸB Pathway[J]. Cancers. 2020, 12(2): 336.

TargetMolCitations

1. Ye Z, Ai X, Yang K, et al.Targeting Microglial Metabolic Rewiring Synergizes with Immune Checkpoint Blockade Therapy for Glioblastoma.Cancer Discovery.2023 2. Jiang Y, Zhao X, Chen J, et al.PM2. 5 induces cardiac malformations via PI3K/akt2/mTORC1 signaling pathway in zebrafish larvae.Environmental Pollution.2023: 121306. 3. Yu D, Cai W, Shen T, et al.PM2. 5 exposure increases dry eye disease risks through corneal epithelial inflammation and mitochondrial dysfunctions.Cell Biology and Toxicology.2023: 1-16. 4. Tang S, Zhong W, Li T, et al.Isochlorogenic acid A alleviates dextran sulfate sodium-induced ulcerative colitis in mice through STAT3/NF-кB pathway.International Immunopharmacology.2023, 118: 109989. 5. Gao J, Wang Y, Zhang W, et al. C20orf27 Promotes Cell Growth and Proliferation of Colorectal Cancer via the TGFβR-TAK1-NFĸB Pathway. Cancers. 2020, 12(2): 336 6. Yu Y, Li Z, Guo R, et al. Ononin, sec-O-β-D-glucosylhamaudol and astragaloside I: antiviral lead compounds identified via high throughput screening and biological validation from traditional Chinese medicine Zhongjing formulary. Pharmacological Research. 2019 May 11;145:104248 7. Chen H, He A, Li H, et al. TSSK4 upregulation in alveolar epithelial type-II cells facilitates pulmonary fibrosis through HSP90-AKT signaling restriction and AT-II apoptosis. Cell Death & Disease. 2021, 12(10): 1-1 8. Shen S C, He F, Cheng C, et al. Uric acid aggravates myocardial ischemia–reperfusion injury via ROS/NLRP3 pyroptosis pathway. Biomedicine & Pharmacotherapy. 2020, 133: 110990. 9. Du T, Yan Z, Zhu S, et al. QKI deficiency leads to osteoporosis by promoting RANKL-inducedosteoclastogenesis and disrupting bone metabolism. Cell Death and Disease. 2020 10. Du T, Yan Z, Zhu S, et al. QKI deficiency leads to osteoporosis by promoting RANKL-inducedosteoclastogenesis and disrupting bone metabolism. Cell Death and Disease. 2020
Hide

Related compound libraries

This product is contained In the following compound libraries:
Autophagy Compound Library DNA Damage & Repair Compound Library Inhibitor Library Bioactive Compound Library Cell Cycle Compound Library Immunology/Inflammation Compound Library Pyroptosis Compound Library Antidepressant Compound Library NF-κB Signaling Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets
GNE-6640 USP7-IN-3 6-Thioguanine GNE-6776 P 22077 USP7/USP47 inhibitor RA-9 N-Ethylmaleimide

TargetMolDose Conversion

You can also refer to dose conversion for different animals. More

TargetMol In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

TargetMolCalculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BAY 11-7082 19542-67-7 Apoptosis Autophagy Cell Cycle/Checkpoint DNA Damage/DNA Repair NF-Κb Others Ubiquitination IκB/IKK DUB IκB kinase cytokine BAY 11 7082 Inhibitor phosphorylation adhesion Deubiquitinase B-cell DUBs IKK BAY 117082 BAY 11-7821 lymphoma leukaemic inhibit ubiquitin I kappa B kinase inflammasome T-cell inhibitor

 

TargetMol