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BMS-833923

BMS-833923
BMS-833923 (XL-139), an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).
Catalog No. T2299Cas No. 1059734-66-5
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Purity:99.74%
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BMS-833923

Catalog No. T2299Cas No. 1059734-66-5
BMS-833923 (XL-139), an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).
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Pack SizePriceAvailabilityQuantity
5 mg$29In Stock
10 mg$44In Stock
25 mg$77In Stock
50 mg$125In Stock
100 mg$226In Stock
200 mg$332In Stock
1 mL x 10 mM (in DMSO)$32In Stock
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Product Introduction

Bioactivity
Description
BMS-833923 (XL-139), an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).
Targets&IC50
BODIPY:21 nM
AliasXL-139
Chemical Properties
Molecular Weight473.57
FormulaC30H27N5O
Cas No.1059734-66-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 88 mg/mL (185.8 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1116 mL10.5581 mL21.1162 mL105.5810 mL
5 mM0.4223 mL2.1116 mL4.2232 mL21.1162 mL
10 mM0.2112 mL1.0558 mL2.1116 mL10.5581 mL
20 mM0.1056 mL0.5279 mL1.0558 mL5.2791 mL
50 mM0.0422 mL0.2112 mL0.4223 mL2.1116 mL
100 mM0.0211 mL0.1056 mL0.2112 mL1.0558 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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