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BPO-27 racemate

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Purity:98.19%

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COA HNMR LCMS HPLC

BPO-27 racemate

Catalog No. T10591Cas No. 1314873-02-3

BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.

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Pack Size	Price	Availability
1 mg	$68	In Stock
5 mg	$198	In Stock
10 mg	$297	In Stock
25 mg	$492	In Stock
50 mg	$718	In Stock
100 mg	$992	In Stock
200 mg	$1,330	In Stock
500 mg	$1,980	In Stock
1 mL x 10 mM (in DMSO)	$229	In Stock

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Product Introduction

Bioactivity

Description	BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.
In vitro	The R enantiomer of BPO-27 inhibits CFTR chloride conductance (IC50: 4 nM), while S enantiomer is inactive. In vitro metabolic stability in hepatic microsomes shows both enantiomers as stable, with less than 5% metabolism in 4 h [1]. (R)-BPO-27 binds near the canonical ATP binding site. Whole-cell patch-clamp studies show linear CFTR currents with a voltage-independent (R)-BPO-27 block mechanism. At a concentration of (R)-BPO-27 that inhibits CFTR chloride current by 50%, the EC50 for ATP activation of CFTR increases from 0.27 to 1.77 mM [2].
In vivo	Following bolus intraperitoneal administration of BPO-27 in mice, serum (R)-1 decays with t1/2 ≈ 1.6 h and gives sustained therapeutic concentrations in the kidney [1].
Alias	BPO-27 (racemate)

Chemical Properties

Molecular Weight	548.34
Formula	C26H18BrN3O6
Cas No.	1314873-02-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (100.3 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8237 mL	9.1184 mL	18.2369 mL	91.1843 mL
5 mM	0.3647 mL	1.8237 mL	3.6474 mL	18.2369 mL
10 mM	0.1824 mL	0.9118 mL	1.8237 mL	9.1184 mL
20 mM	0.0912 mL	0.4559 mL	0.9118 mL	4.5592 mL
50 mM	0.0365 mL	0.1824 mL	0.3647 mL	1.8237 mL
100 mM	0.0182 mL	0.0912 mL	0.1824 mL	0.9118 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc