Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BQR-695 (NVP-BQR695) is a phosphatidylinositol 4-kinase (PI4K) inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 64.00 | |
10 mg | In stock | $ 89.00 | |
25 mg | In stock | $ 197.00 | |
50 mg | In stock | $ 289.00 | |
100 mg | In stock | $ 455.00 | |
500 mg | In stock | $ 987.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 70.00 |
Description | BQR-695 (NVP-BQR695) is a phosphatidylinositol 4-kinase (PI4K) inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively. |
Targets&IC50 | PI4KIIIβ (human):80 nM, P. falciparum (PI4KIIIβ):3.5 nM |
In vitro | BQR695 demonstrates no toxicity towards mature red blood cells (RBCs), triggers a schizont-stage halt akin to the effects seen in imidazopyrazine-treated parasites, and shows cross-resistance with imidazopyrazine-resistant strains. Administering 0.5 μM of KAI407 or BQR695 leads to the redistribution of GFP-PHOsh2 to the parasite's plasma membrane, indicating a decrease in intracellular PI4P due to the inhibition of PfPI4K activity. |
Synonyms | BQR695, NVP-BQR695 |
Molecular Weight | 352.39 |
Formula | C19H20N4O3 |
CAS No. | 1513879-21-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL
You can also refer to dose conversion for different animals. More
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BQR-695 1513879-21-4 Microbiology/Virology PI3K/Akt/mTOR signaling PI3K PI4K Parasite PI4 kinases BQR695 NVP-BQR-695 BQR 695 Inhibitor inhibit Phosphatidylinositol 4 kinases NVP-BQR 695 NVP-BQR695 inhibitor