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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $38 | In Stock | |
10 mg | $53 | In Stock | |
25 mg | $118 | In Stock | |
50 mg | $173 | In Stock | |
100 mg | $273 | In Stock | |
200 mg | $388 | In Stock | |
1 mL x 10 mM (in DMSO) | $42 | In Stock |
Description | BQR-695 (NVP-BQR695) is a phosphatidylinositol 4-kinase (PI4K) inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively. |
Targets&IC50 | PI4KIIIβ (human):80 nM, P. falciparum (PI4KIIIβ):3.5 nM |
In vitro | BQR695 demonstrates no toxicity towards mature red blood cells (RBCs), triggers a schizont-stage halt akin to the effects seen in imidazopyrazine-treated parasites, and shows cross-resistance with imidazopyrazine-resistant strains. Administering 0.5 μM of KAI407 or BQR695 leads to the redistribution of GFP-PHOsh2 to the parasite's plasma membrane, indicating a decrease in intracellular PI4P due to the inhibition of PfPI4K activity. |
Alias | BQR695, NVP-BQR695 |
Molecular Weight | 352.39 |
Formula | C19H20N4O3 |
Cas No. | 1513879-21-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (141.89 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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