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Bay 11-7085

Catalog No. T1934   CAS 196309-76-9
Synonyms: BAY 11-7083

Bay 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).

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Bay 11-7085 Chemical Structure
Bay 11-7085, CAS 196309-76-9
Pack Size Availability Price/USD Quantity
2 mg In stock $ 30.00
5 mg In stock $ 43.00
10 mg In stock $ 61.00
25 mg In stock $ 77.00
50 mg In stock $ 126.00
100 mg In stock $ 207.00
200 mg In stock $ 269.00
1 mL * 10 mM (in DMSO) In stock $ 56.00
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Purity: 99.43%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Bay 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).
Targets&IC50 IκBα phosphorylation:10 μM
Kinase Assay In Gel Kinase Assay: In gel kinase assay for the proteins that phosphorylate IκB-α is carried out as detailed below. Whole cell extracts are prepared from HUVEC treated with TNFα (100 units/ml) for 15 min in the presence or absence of inhibitor (20 μM, pretreatment for 1 h) as indicated. Proteins are separated on a 10% SDS gel containing 0.5 mg/ml HIS-IκB-α. Gels are washed two times in 20% propanol, 50 mM Hepes, pH 7.6, for 30 min and two times in buffer A (50 mM Hepes, pH 7.6, 5 mM 2-mercaptoethanol) for 30 min, followed by a 1-h incubation with buffer A containing 6 M urea, 1 h each in 3, 1.5, and 0.75 M urea in buffer A and 0.05% Tween 20 and 1 h in buffer A with 0.05% Tween 20. The kinase assay is carried out for 1 h at 30?°C in the presence of 50 μM ATP, 5 μCi/ml [32P]ATP, 20 mM Hepes, pH 7.6, 20 mM MgCl2, 20 mM β-glycerophosphate, 20 mM p-nitrophenyl phosphate, 1 mM sodium vanadate, 2 mM dithiothreitol. The gel is washed with 5% trichloroacetic acid and 1% sodium pyrophosphate, dried, and exposed to film. A separate gel with no HIS-IκB-α is assayed as a control.
Cell Research Human umbilical vein endothelial cells (HUVEC) are isolated and maintained in culture. Cell toxicity is assessed by morphology and by MTT assay.(Only for Reference)
Synonyms BAY 11-7083
Molecular Weight 249.33
Formula C13H15NO2S
CAS No. 196309-76-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 24.9 mg/mL (100 mM)

Ethanol: 24.9 mg/mL (100 mM)

TargetMolReferences and Literature

1. Pierce JW, et al. J Biol Chem. 1997, 272(34), 21096-21103. 2. Koedel U, et al. J Infect Dis. 2000, 182(5), 1437-1445. 3. Mabuchi S, et al. Clin Cancer Res. 2004, 10(22), 7645-7654. 4. Hussain AR, et al. PLoS One. 2012, 7(6), e39945.

TargetMolCitations

1. Li J, Xiao X, Ou Y, et al.USP51/PD‐L1/ITGB1‐deployed juxtacrine interaction plays a cell‐intrinsic role in promoting chemoresistant phenotypes in non‐small cell lung cancer.Cancer Communications.2023

Related compound libraries

This product is contained In the following compound libraries:
Highly Selective Inhibitor Library Anti-Liver Cancer Compound Library Bioactive Compound Library Apoptosis Compound Library NO PAINS Compound Library Anti-Breast Cancer Compound Library Anti-Aging Compound Library Antidepressant Compound Library Anti-Cancer Compound Library Oxidation-Reduction Compound Library

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Keywords

Bay 11-7085 196309-76-9 Apoptosis NF-Κb IκB/IKK Ferroptosis NF-κB BAY 11-7085 BAY 11-7083 inhibit Nuclear factor-κB Inhibitor Bay 11 7085 Bay 117085 Nuclear factor-kappaB inhibitor

 

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