Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bepridil hydrochloride (CERM 1978) is a calcium channel blocker and also inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 41.00 | |
10 mg | In stock | $ 54.00 | |
25 mg | In stock | $ 98.00 | |
50 mg | In stock | $ 135.00 | |
100 mg | In stock | $ 189.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 45.00 |
Description | Bepridil hydrochloride (CERM 1978) is a calcium channel blocker and also inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels. |
In vitro | Bepridil (1-100 microM) inhibited the K(ATP) channel current in a concentration-dependent manner. The IC(50) value of bepridil was estimated to be 10.5 microM for outward K(ATP) channel currents (holding potential, +60 mV) and 6.6 microM for inward K(ATP) channel currents (holding potential, -60 mV). Bepridil (0.1-30 microM) also inhibited K(Na) channel currents measured at the holding potential of -60 mV, in a concentration-dependent manner with an IC(50) value of 2.2 microM [2]. |
In vivo | The predominant effects of Bepridil (cumulative dose = 9.0 mg/kg i.v.) in the conscious rat were reduced coronary vascular resistance and heart rate. Bepridil showed selectivity for the coronary circulation since systemic vascular resistance was not significantly reduced until cumulative i.v. dosage of 21.0 mg/kg was administered [1]. |
Synonyms | CERM 1978 |
Molecular Weight | 403 |
Formula | C24H35ClN2O |
CAS No. | 68099-86-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 130 mg/mL (322.58 mM)
You can also refer to dose conversion for different animals. More
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Bepridil hydrochloride 68099-86-5 Membrane transporter/Ion channel Metabolism Calcium Channel CERM1978 CERM 1978 inhibit Ca2+ channels Bepridil CERM-1978 Inhibitor Ca channels Bepridil Hydrochloride inhibitor