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Beta-mangostin

Catalog No. TN1019 CAS 20931-37-7

Synonyms: β-Mangostin

Beta-mangostin (β-Mangostin) is a xanthone compound with antibacterial and antimalarial activities. Beta-mangostin present in Cratoxylum arborescens and exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. Beta-mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC50 of 3.00 μg/mL. Beta-mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic).

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Beta-mangostin, CAS 20931-37-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 78.00
5 mg	In stock	$ 185.00
10 mg	In stock	$ 273.00
25 mg	In stock	$ 459.00
50 mg	In stock	$ 673.00
1 mL * 10 mM (in DMSO)	In stock	$ 212.00

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Purity: 99.69%

Purity: 98.01%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Beta-mangostin (β-Mangostin) is a xanthone compound with antibacterial and antimalarial activities. Beta-mangostin present in Cratoxylum arborescens and exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. Beta-mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC50 of 3.00 μg/mL. Beta-mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic).
In vitro	Beta-Mangostin induces the intrinsic apoptosis pathway in HL60 cells by generating reactive oxygen species and suppressing the HSP70 gene, coupled with a G0/G1 cell-cycle arrest[2].
Source	Natural Products > Clusiaceae > Garcinia

Synonyms	β-Mangostin
Molecular Weight	424.49
Formula	C25H28O6
CAS No.	20931-37-7

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 24 mg/mL (56.53 mM)

References and Literature

1. Syam S, et al. β Mangostin suppress LPS-induced inflammatory response in RAW 264.7 macrophages in vitro and carrageenan-induced peritonitis in vivo. J Ethnopharmacol. 2014 Apr 28;153(2):435-45. 2. Chien-Feng Huang, et al.β-mangostin suppresses human hepatocellular carcinoma cell invasion through inhibition of MMP-2 and MMP-9 expression and activating the ERK and JNK pathways. Environ Toxicol. 2017 Nov;32(11):2360-2370. 3. Fatima Abdelmutaal Ahmed Omer, et al. Beta-mangostin from Cratoxylum arborescens activates the intrinsic apoptosis pathway through reactive oxygen species with downregulation of the HSP70 gene in the HL60 cells associated with a G 0/G 1 cell-cycle arrest. Tumour Biol. 2017 Nov;39(11):1010428317731451. 4. K Likhitwitayawuid, et al. Antimalarial xanthones from Garcinia cowa. Planta Med. 1998 Feb;64(1):70-2. 5. Sunit Suksamrarn, et al. Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana. Chem Pharm Bull (Tokyo). 2003 Jul;51(7):857-9.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Tobacco Monomer Library Antiparasitic Natural Product Library Anti-Parasitic Compound Library Anti-Cancer Compound Library Anti-Tumor Natural Product Library Human Metabolite Library Selected Plant-Sourced Compound Library Anti-Bacterial Compound Library Traditional Chinese Medicine Monomer Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Beta-mangostin 20931-37-7 Apoptosis Microbiology/Virology Antibacterial Parasite Beta mangostin Bacterial pathway β-Mangostin carcinoma migration b-Mangostin antibacterial inhibit cell hepatocellular intrinsic antimalarial Betamangostin beta-Mangostin cell-cycle leukaemic Inhibitor arrest invasion inhibitor

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