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CCG-1423

Catalog No. T2014 CAS 285986-88-1

Synonyms: CCG1423, CCG 1423

CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.

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CCG-1423, CAS 285986-88-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.
Targets&IC50	G2019S LRRK2:1.85 nM, LRRK2 wild-type:1.28 nM
Cell Research	Cells in normal culture medium are plated (2,000 per well) in a 96-well plate coated with laminin. After attachment, the medium is replaced with serum-free medium (0% FBS) with 30 μmol/L LPA with or without 300 nM CCG-1423. Fresh LPA with or without CCG-1423 is added at day 5 to ensure that LPA and compound are present throughout the experiment. On day 8, WST-1 reagent is added to the wells for 1 h and absorbance at 450 nm is read using a Victor plate reader.(Only for Reference)

Synonyms	CCG1423, CCG 1423
Molecular Weight	454.75
Formula	C18H13ClF6N2O3
CAS No.	285986-88-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: 4 mg/mL (8.79 mM), warmed

H2O: <1 mg/mL

DMSO: 83 mg/mL (182.5 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Evelyn CR, et al. Mol Cancer Ther. 2007, 6(8), 2249-2260. 2. Mae S, et al. Biochem Biophys Res Commun. 2010, 393(4), 877-882. 3. Chong NW, et al. PLoS One. 2012, 7(7), e40966. 4. Johnson LA, et al. Inflamm Bowel Dis. 2014, 20(1), 154-165.

Citations

1. Liu W X, Tan S J, Wang Y F, et al. Melatonin promotes the proliferation of primordial germ cell‐like cells derived from porcine skin‐derived stem cells: A mechanistic analysis. Journal of Pineal Research. 2022

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Autophagy Compound Library GPCR Compound Library Anti-Cancer Metabolism Compound Library Anti-Cardiovascular Disease Compound Library Glutamine Metabolism Compound Library Inhibitor Library Neural Regeneration Compound Library Cell Cycle Compound Library Kinase Inhibitor Library

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Related compounds with same targets

PF-06454589 JH-II-127 URMC-099 CZC-25146 hydrochloride EB-42486 CZC-54252 hydrochloride CZC-25146 LRRK2-IN-1

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CCG-1423 285986-88-1 G蛋白偶联受体 MAPK信号通路细胞周期自噬 LRRK2 Ras Rho PC-3 conformational restriction mice Inhibitor bioisostere CCG1423 glucose tolerance CCG 1423 metastasis Apoptosis inhibit prostate,serum inhibitor

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