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CCG-1423

Catalog No. T2014   CAS 285986-88-1
Synonyms: PC-3, CCG-1423, conformational restriction, mice, Inhibitor, bioisostere, CCG1423, glucose tolerance, CCG 1423, metastasis, Apoptosis, inhibit, prostate,serum, Ras

CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
CCG-1423, CAS 285986-88-1
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Purity: 98%
Biological Description
Chemical Properties
Storage & Solubility Information
Description CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.
Targets&IC50 G2019S LRRK2:1.85 nM, LRRK2 wild-type:1.28 nM
Cell Research Cells in normal culture medium are plated (2,000 per well) in a 96-well plate coated with laminin. After attachment, the medium is replaced with serum-free medium (0% FBS) with 30 μmol/L LPA with or without 300 nM CCG-1423. Fresh LPA with or without CCG-1423 is added at day 5 to ensure that LPA and compound are present throughout the experiment. On day 8, WST-1 reagent is added to the wells for 1 h and absorbance at 450 nm is read using a Victor plate reader.(Only for Reference)
Synonyms PC-3, CCG-1423, conformational restriction, mice, Inhibitor, bioisostere, CCG1423, glucose tolerance, CCG 1423, metastasis, Apoptosis, inhibit, prostate,serum, Ras
Molecular Weight 454.75
Formula C18H13ClF6N2O3
CAS No. 285986-88-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: 4 mg/mL (8.79 mM), warmed

H2O: <1 mg/mL

DMSO: 83 mg/mL (182.5 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Liu W X, Tan S J, Wang Y F, et al. Melatonin promotes the proliferation of primordial germ cell‐like cells derived from porcine skin‐derived stem cells: A mechanistic analysis. Journal of Pineal Research. 2022 1. Evelyn CR, et al. Mol Cancer Ther. 2007, 6(8), 2249-2260. 2. Mae S, et al. Biochem Biophys Res Commun. 2010, 393(4), 877-882. 3. Chong NW, et al. PLoS One. 2012, 7(7), e40966. 4. Johnson LA, et al. Inflamm Bowel Dis. 2014, 20(1), 154-165.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Compound Library Autophagy Compound Library GPCR Compound Library Anti-Cancer Metabolism Compound Library Anti-Cardiovascular Disease Compound Library Glutamine Metabolism Compound Library Inhibitor Library Neural Regeneration Compound Library Cell Cycle Compound Library Kinase Inhibitor Library

Related Products

Related compounds with same targets
PF-06454589 JH-II-127 URMC-099 CZC-25146 hydrochloride EB-42486 CZC-54252 hydrochloride CZC-25146 LRRK2-IN-1

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.