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CCG-1423

Catalog No. T2014 CAS 285986-88-1

Synonyms: CCG1423

CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.

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CCG-1423, CAS 285986-88-1

Pack Size	Availability	Price/USD
5 mg	In stock	$ 32.00
10 mg	In stock	$ 52.00
25 mg	In stock	$ 97.00
50 mg	In stock	$ 165.00
100 mg	In stock	$ 275.00
200 mg	In stock	$ 428.00
500 mg	In stock	$ 695.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.98%

Purity: 99.63%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.
Targets&IC50	LRRK2 (WT):1.28 nM, LRRK2 (G2019S):1.85 nM
In vivo	In H9c2 cells, CCG-1423 inhibits MRTF nuclear localization and completely blocks the activity of STARS proximal reporter genes. It also suppresses TGF-β-induced fibrogenesis in human colon myofibroblasts. Under the influence of CCG-1423 and LY294002, mouse embryonic stem cells differentiate into the mesendoderm. In melanoma cells (A375M2 and SK-Mel-147) overexpressing RhoC, CCG-1423 selectively inhibits cell proliferation.
Cell Research	Cells in normal culture medium are plated (2,000 per well) in a 96-well plate coated with laminin. After attachment, the medium is replaced with serum-free medium (0% FBS) with 30 μmol/L LPA with or without 300 nM CCG-1423. Fresh LPA with or without CCG-1423 is added at day 5 to ensure that LPA and compound are present throughout the experiment. On day 8, WST-1 reagent is added to the wells for 1 h and absorbance at 450 nm is read using a Victor plate reader.(Only for Reference)

Synonyms	CCG1423
Molecular Weight	454.75
Formula	C18H13ClF6N2O3
CAS No.	285986-88-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 4 mg/mL (8.79 mM), Heating is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 83 mg/mL (182.5 mM)

References and Literature

1. Evelyn CR, et al. Mol Cancer Ther. 2007, 6(8), 2249-2260. 2. Mae S, et al. Biochem Biophys Res Commun. 2010, 393(4), 877-882. 3. Chong NW, et al. PLoS One. 2012, 7(7), e40966. 4. Johnson LA, et al. Inflamm Bowel Dis. 2014, 20(1), 154-165.

Citations

1. Liu W X, Tan S J, Wang Y F, et al. Melatonin promotes the proliferation of primordial germ cell‐like cells derived from porcine skin‐derived stem cells: A mechanistic analysis. Journal of Pineal Research. 2022

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Anti-Neurodegenerative Disease Compound Library GPCR Compound Library Kinase Inhibitor Library Inhibitor Library Anti-Cancer Active Compound Library HIF-1 Signaling Pathway Compound Library Anti-Obesity Compound Library Anti-Cardiovascular Disease Compound Library Anti-Cancer Compound Library

Related Products

Related compounds with same targets

LRRK2 inhibitor 1 CZC-25146 hydrochloride LRRK2-IN-10 PF-06447475 CZC-25146 MK-1468 GSK2578215A PF-06454589

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CCG-1423 285986-88-1 Autophagy Cell Cycle/Checkpoint GPCR/G Protein MAPK Rho Ras LRRK2 PC-3 conformational restriction mice Inhibitor bioisostere CCG 1423 glucose tolerance metastasis Apoptosis CCG1423 inhibit prostate,serum inhibitor

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