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CGP 53353

CGP 53353
CGP 53353 (DAPH-7) is a PKC inhibitor with inhibitory effects on PKCβII and PKCβI and can be used to study atherosclerosis.
Catalog No. T22650Cas No. 145915-60-2
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Purity:98.11%
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CGP 53353

Purity: 98.11%
Catalog No. T22650Alias DAPH-7Cas No. 145915-60-2

CGP 53353 (DAPH-7) is a PKC inhibitor with inhibitory effects on PKCβII and PKCβI and can be used to study atherosclerosis.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
5 mg$129In Stock
10 mg$198In Stock
25 mg$455In Stock
50 mg$787In Stock
100 mg$1,280In Stock
1 mL x 10 mM (in DMSO)$143In Stock
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Product Introduction

Bioactivity
Description
CGP 53353 (DAPH-7) is a PKC inhibitor with inhibitory effects on PKCβII and PKCβI and can be used to study atherosclerosis.
Targets&IC50
PKCβI:3.8 mM, PKCβII:0.41 mM
In vitro
In A10 cells, CGP-53353 (DAPH-7) inhibits glucose-induced cell proliferation when administered at 1 μM for 48-96 hours[1].
At a concentration of 1 μM for the initial 0-48 hours, CGP-53353 inhibits the glucose-induced increase and acceleration of DNA synthesis in A10 cells. It also blocks the glucose-induced increase in the percentage of S-phase cells[1].
AliasDAPH-7
Chemical Properties
Molecular Weight365.33
FormulaC20H13F2N3O2
Cas No.145915-60-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: < 7.31 mg/mL
DMSO: 50 mg/mL (136.86 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7373 mL13.6863 mL27.3725 mL136.8626 mL
5 mM0.5475 mL2.7373 mL5.4745 mL27.3725 mL
10 mM0.2737 mL1.3686 mL2.7373 mL13.6863 mL
20 mM0.1369 mL0.6843 mL1.3686 mL6.8431 mL
50 mM0.0547 mL0.2737 mL0.5475 mL2.7373 mL
100 mM0.0274 mL0.1369 mL0.2737 mL1.3686 mL

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