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CGP 53353

Catalog No. T22650Cas No. 145915-60-2
Alias DAPH-7

CGP 53353 (DAPH-7) is a PKC inhibitor with inhibitory effects on PKCβII and PKCβI and can be used to study atherosclerosis.

CGP 53353

CGP 53353

Purity: 98.11%
Catalog No. T22650Alias DAPH-7Cas No. 145915-60-2
CGP 53353 (DAPH-7) is a PKC inhibitor with inhibitory effects on PKCβII and PKCβI and can be used to study atherosclerosis.
Pack SizePriceAvailabilityQuantity
5 mg$129In Stock
10 mg$198In Stock
25 mg$455In Stock
50 mg$787In Stock
100 mg$1,280In Stock
1 mL x 10 mM (in DMSO)$143In Stock
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Purity:98.11%
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Product Introduction

Bioactivity
Description
CGP 53353 (DAPH-7) is a PKC inhibitor with inhibitory effects on PKCβII and PKCβI and can be used to study atherosclerosis.
Targets&IC50
PKCβII:0.41 mM, PKCβI:3.8 mM
In vitro
In A10 cells, CGP-53353 (DAPH-7) inhibits glucose-induced cell proliferation when administered at 1 μM for 48-96 hours[1].
At a concentration of 1 μM for the initial 0-48 hours, CGP-53353 inhibits the glucose-induced increase and acceleration of DNA synthesis in A10 cells. It also blocks the glucose-induced increase in the percentage of S-phase cells[1].
AliasDAPH-7
Chemical Properties
Molecular Weight365.33
FormulaC20H13F2N3O2
Cas No.145915-60-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: < 7.31 mg/mL
DMSO: 50 mg/mL (136.86 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7373 mL13.6863 mL27.3725 mL136.8626 mL
5 mM0.5475 mL2.7373 mL5.4745 mL27.3725 mL
10 mM0.2737 mL1.3686 mL2.7373 mL13.6863 mL
20 mM0.1369 mL0.6843 mL1.3686 mL6.8431 mL
50 mM0.0547 mL0.2737 mL0.5475 mL2.7373 mL
100 mM0.0274 mL0.1369 mL0.2737 mL1.3686 mL

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