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CGP 35348

Catalog No. T21793 CAS 123690-79-9

CGP 35348 is a selective antagonist of GABAB receptor (EC50 = 34 μM). CGP 35348 can be used in studies of neuromuscular coordination and spatial learning after neonatal brain damage in albino mice.

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CGP 35348, CAS 123690-79-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 44.00
2 mg	In stock	$ 64.00
5 mg	In stock	$ 98.00
10 mg	In stock	$ 172.00
25 mg	In stock	$ 372.00
50 mg	In stock	$ 597.00
100 mg	In stock	$ 852.00
500 mg	In stock	$ 1,730.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	CGP 35348 is a selective antagonist of GABAB receptor (EC50 = 34 μM). CGP 35348 can be used in studies of neuromuscular coordination and spatial learning after neonatal brain damage in albino mice.
In vivo	In male Wistar rats, CGP 35348(100, 300, and 900 mg/kg) produced an increase in the duration of non-REM sleep and rapid eye movement (REM) sleep and reduced strongly spike-wave discharges[2].

Molecular Weight	225.22
Formula	C8H20NO4P
CAS No.	123690-79-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: < 2.25 mg/mL (10 mM, insoluble or slightly soluble)

References and Literature

1. Q Gillani, et al. CGP 35348, GABA B receptor antagonist, has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage. Biomed Res Int. 2014;2014:295215. 2. A Puigcerver, et al. Effects of the GABAB antagonist CGP 35348 on sleep-wake states, behaviour, and spike-wave discharges in old rats. Brain Res Bull. 1996;40(3):157-62. 3. H R Olpe,et al. CGP 35348: a centrally active blocker of GABAB receptors. CGP 35348: a centrally active blocker of GABAB receptors

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Neurodegenerative Disease Compound Library Neurotransmitter Receptor Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library Bioactive Compound Library Neuronal Signaling Compound Library ReFRAME Related Library

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Keywords

CGP 35348 123690-79-9 Membrane transporter/Ion channel Neuroscience GABA Receptor spatial learning neuromuscular neonatal damage brain penetrant Gamma-aminobutyric acid Receptor centrally GABAB Inhibitor CGP35348 γ-Aminobutyric acid Receptor CGP-35348 inhibit active inhibitor

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