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CRT0066854 hydrochloride
CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively.
Catalog No. T10888Cas No. 2250019-91-9
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Purity:97.51%
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CRT0066854 hydrochloride
Catalog No. T10888Cas No. 2250019-91-9
CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $33 | In Stock | |
| 2 mg | $47 | In Stock | |
| 5 mg | $77 | In Stock | |
| 10 mg | $127 | In Stock | |
| 25 mg | $215 | In Stock | |
| 50 mg | $319 | In Stock | |
| 100 mg | $455 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $94 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively. |
| Targets&IC50 | ROCKII:620 nM, PKCζ:639 nM |
| In vitro | CRT0066854 hydrochloride replaces the crucial Asn-Phe-Asp motif, which is part of the adenosine binding pocket and joins with the acidic patch used by the PKC substrate rich in arginine. CRT0066854 hydrochloric acid Salt (0.2-1.2μM; 6 days) can restore polarized morphogenesis. Among the dysplastic H-Ras spheroids, the maximum proportion of PSAL spheroids was 1.2 μM at a lower dose[1]. |
| Molecular Weight | 488.48 |
| Formula | C24H27Cl2N5S |
| Cas No. | 2250019-91-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (92.12 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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