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CXCR2-IN-1

Catalog No. T10905 CAS 1873376-49-8

CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.

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CXCR2-IN-1, CAS 1873376-49-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 122.00
5 mg	In stock	$ 287.00
10 mg	In stock	$ 413.00
25 mg	In stock	$ 692.00
50 mg	In stock	$ 985.00
100 mg	In stock	$ 1,330.00
500 mg	In stock	$ 2,660.00

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Purity: 99.53%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.
Targets&IC50	CXCR2:9.3(pIC50)
In vitro	CXCR2 plays an important role in the activation and recruitment of neutrophils to the site of inflammation. CXCR2-IN-1 showed good central nervous system penetration characteristics (Br / Bl> 0.45)[1].
In vivo	CXCR2-IN-1 has shown efficacy in oral copper ketone-induced demyelination models by oral administration, providing evidence to support CXCR2 as a potential therapeutic target for the treatment of demyelinating diseases such as multiple sclerosis[1].

Molecular Weight	476.35
Formula	C19H20Cl2FN3O4S
CAS No.	1873376-49-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.5 mg/mL (9.4 mM), Sonification is recommended.

References and Literature

1. Xu H, et al. Discovery of CNS Penetrant CXCR2 Antagonists for the Potential Treatment of CNS Demyelinating Disorders. ACS Med Chem Lett. 2016 Feb 8;7(4):397-402.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library GPCR Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CXCR2-IN-1 1873376-49-8 Autophagy GPCR/G Protein Immunology/Inflammation CXCR CXCR-2-IN-1 CXCR2 IN 1 CXCR2IN1 inhibitor inhibit

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