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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $73 | In Stock | |
5 mg | $172 | In Stock | |
10 mg | $247 | In Stock | |
25 mg | $415 | In Stock | |
50 mg | $591 | In Stock | |
100 mg | $798 | In Stock | |
500 mg | Inquiry | In Stock |
Description | CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent. |
In vitro | CXCR2 plays an important role in the activation and recruitment of neutrophils to the site of inflammation. CXCR2-IN-1 showed good central nervous system penetration characteristics (Br / Bl> 0.45)[1]. |
In vivo | CXCR2-IN-1 has shown efficacy in oral copper ketone-induced demyelination models by oral administration, providing evidence to support CXCR2 as a potential therapeutic target for the treatment of demyelinating diseases such as multiple sclerosis[1]. |
Molecular Weight | 476.35 |
Formula | C19H20Cl2FN3O4S |
Cas No. | 1873376-49-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||
Solubility Information | DMSO: 4.5 mg/mL (9.4 mM) | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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