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CXCR2-IN-1
🥰Excellent
Catalog No. T10905Cas No. 1873376-49-8
CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.
CXCR2-IN-1
🥰Excellent
Purity: 99.53%
Catalog No. T10905Cas No. 1873376-49-8
CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $73 | In Stock | |
| 5 mg | $172 | In Stock | |
| 10 mg | $247 | In Stock | |
| 25 mg | $415 | In Stock | |
| 50 mg | $591 | In Stock | |
| 100 mg | $798 | In Stock | |
| 500 mg | Inquiry | In Stock |
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Purity:99.53%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent. |
| Targets&IC50 | CXCR2:9.3(pIC50) |
| In vitro | CXCR2 is crucial for activating and recruiting neutrophils to inflammation sites. CXCR2-IN-1 demonstrated favorable central nervous system penetration (Br/Bl>0.45) [1]. |
| In vivo | CXCR2-IN-1 has shown efficacy in oral copper ketone-induced demyelination models by oral administration, providing evidence to support CXCR2 as a potential therapeutic target for the treatment of demyelinating diseases such as multiple sclerosis[1]. |
| Molecular Weight | 476.35 |
| Formula | C19H20Cl2FN3O4S |
| Cas No. | 1873376-49-8 |
| Smiles | CN1CCC(CC1)S(=O)(=O)c1c(Cl)ccc(NC(=O)Nc2cccc(F)c2Cl)c1O |
| Relative Density. | 1.528 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | DMSO: 4.5 mg/mL (9.4 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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