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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $37 | In Stock | |
2 mg | $51 | In Stock | |
5 mg | $76 | In Stock | |
10 mg | $122 | In Stock | |
25 mg | $222 | In Stock | |
50 mg | $372 | In Stock | |
100 mg | $597 | In Stock | |
1 mL x 10 mM (in DMSO) | $119 | In Stock |
Description | Elbasvir (MK-8742) is an inhibitor of nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) being developed as a component of treatment regimens for chronic HCV infection. |
Targets&IC50 | NS5A:2.2 pM (EC50) |
In vitro | Elbasvir potently inhibits hepatitis C virus (HCV) non-structural protein 5A (NS5A) with an EC50 value of 2.2 pM in Huh7 human liver cancer cells expressing pH77S.3/GLuc2A, a cell-culture adapted HCV16 genotype 1a derivative and luciferase reporter, following a 48-hour exposure in vitro [1,2]. NS5A is essential for HCV RNA synthesis and viral assembly, and elbasvir inhibits the assembly of new viral replicase complexes when used at a concentration of 50 pM [2]. It exhibits potent inhibitory activity against a broad range of HCV genotypes with EC50 values of 0.0002-34 nM in Huh7 cells expressing replicons of HCV genotype 4 NS5A and EC50 values of less than 0.2 nM for replicons from all other tested genotypes except 2b [1,3,4]. Formulations containing elbasvir have been used alone and in combination with NS3/4A protease inhibitors in the treatment of HCV. |
Alias | MK-8742 |
Molecular Weight | 882.02 |
Formula | C49H55N9O7 |
Cas No. | 1370468-36-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (56.69 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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