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Elbasvir

Elbasvir
Elbasvir (MK-8742) is an inhibitor of nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) being developed as a component of treatment regimens for chronic HCV infection.
Catalog No. T4544Cas No. 1370468-36-2
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Purity:99.85%
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Elbasvir

Purity: 99.85%
Catalog No. T4544Alias MK-8742Cas No. 1370468-36-2

Elbasvir (MK-8742) is an inhibitor of nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) being developed as a component of treatment regimens for chronic HCV infection.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$37In Stock
2 mg$51In Stock
5 mg$76In Stock
10 mg$122In Stock
25 mg$222In Stock
50 mg$372In Stock
100 mg$597In Stock
1 mL x 10 mM (in DMSO)$119In Stock
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Product Introduction

Bioactivity
Description
Elbasvir (MK-8742) is an inhibitor of nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) being developed as a component of treatment regimens for chronic HCV infection.
Targets&IC50
NS5A:2.2 pM (EC50)
In vitro
Elbasvir potently inhibits hepatitis C virus (HCV) non-structural protein 5A (NS5A) with an EC50 value of 2.2 pM in Huh7 human liver cancer cells expressing pH77S.3/GLuc2A, a cell-culture adapted HCV16 genotype 1a derivative and luciferase reporter, following a 48-hour exposure in vitro [1,2]. NS5A is essential for HCV RNA synthesis and viral assembly, and elbasvir inhibits the assembly of new viral replicase complexes when used at a concentration of 50 pM [2]. It exhibits potent inhibitory activity against a broad range of HCV genotypes with EC50 values of 0.0002-34 nM in Huh7 cells expressing replicons of HCV genotype 4 NS5A and EC50 values of less than 0.2 nM for replicons from all other tested genotypes except 2b [1,3,4]. Formulations containing elbasvir have been used alone and in combination with NS3/4A protease inhibitors in the treatment of HCV.
AliasMK-8742
Chemical Properties
Molecular Weight882.02
FormulaC49H55N9O7
Cas No.1370468-36-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (56.69 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.1338 mL5.6688 mL11.3376 mL56.6881 mL
5 mM0.2268 mL1.1338 mL2.2675 mL11.3376 mL
10 mM0.1134 mL0.5669 mL1.1338 mL5.6688 mL
20 mM0.0567 mL0.2834 mL0.5669 mL2.8344 mL
50 mM0.0227 mL0.1134 mL0.2268 mL1.1338 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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