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Epirubicin hydrochloride

🥰Excellent
Catalog No. T0125Cas No. 56390-09-1
Alias Pharmorubicin, Epirubicin HCl, 4'-Epidoxorubicin hydrochloride, 4'-epidoxorubicin HCl

Epirubicin hydrochloride (Pharmorubicin) is an adriamycin derivative, a topoisomerase (Topo) inhibitor, and a Forkhead box protein p3 (Foxp3) inhibitor. Epirubicin hydrochloride has antitumor activity.

Epirubicin hydrochloride

Epirubicin hydrochloride

🥰Excellent
Purity: 99.79%
Catalog No. T0125Alias Pharmorubicin, Epirubicin HCl, 4'-Epidoxorubicin hydrochloride, 4'-epidoxorubicin HClCas No. 56390-09-1
Epirubicin hydrochloride (Pharmorubicin) is an adriamycin derivative, a topoisomerase (Topo) inhibitor, and a Forkhead box protein p3 (Foxp3) inhibitor. Epirubicin hydrochloride has antitumor activity.
Pack SizePriceAvailabilityQuantity
2 mg$33In Stock
5 mg$51In Stock
10 mg$81In Stock
25 mg$153In Stock
50 mg$252In Stock
100 mg$342In Stock
500 mg$827In Stock
1 mL x 10 mM (in DMSO)$67In Stock
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Purity:99.79%
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Product Introduction

Bioactivity
Description
Epirubicin hydrochloride (Pharmorubicin) is an adriamycin derivative, a topoisomerase (Topo) inhibitor, and a Forkhead box protein p3 (Foxp3) inhibitor. Epirubicin hydrochloride has antitumor activity.
In vitro
METHODS: Neuroglioma cells U-87 and neuronal primary cultures were treated with Epirubicin hydrochloride (0.5-100 µM) for 48 h. Cell viability was measured by MTT assay.
RESULTS: Epirubicin significantly reduced the viability of rat U-87 cells in a concentration-dependent manner, with an IC50 of 6.3 µM. In contrast to U-87 glioma cells, rat normal neuronal cells were resistant to Epirubicin. [1]
METHODS: Human breast cancer cells MDA-MB-231 and SK-BR-3 were treated with Epirubicin hydrochloride (2-3 µM) for 48 h, and apoptosis was detected by Flow cytometry.
RESULTS: Epirubicin significantly increased sub-G cells in G2/M block. [2]
In vivo
METHODS: To test the antitumor activity in vivo, Epirubicin hydrochloride (7 mg/kg) was administered intravenously three times at four-day intervals to BALB/c nu/nu nude mice bearing MDA-MB-231 xenografts.
RESULTS: Epirubicin reduced tumor growth by half and resulted in a more than 10% weight loss. the IR value of Epirubicin at 7 mg/kg was 53.3%. [2]
Cell Research
Hep G2 cells (500 cells/well, monolayer) are plated in a 96-well plate. The next day the cells are treated with Epirubicin in the medium. At the end of the incubation periods, 15% volume of MTT dye solution is added. After 1 hr of incubation at 37℃, an equal volume of solubilization/stop solution (dimethylsul-foxide) is added to each well for an additional 1 hr incubation. The absorbance of the reaction solution at 570 nm is recorded.(Only for Reference)
AliasPharmorubicin, Epirubicin HCl, 4'-Epidoxorubicin hydrochloride, 4'-epidoxorubicin HCl
Chemical Properties
Molecular Weight579.98
FormulaC27H30ClNO11
Cas No.56390-09-1
SmilesCl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
Relative Density.1.61g/cm3
Storage & Solubility Information
Storagestore at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
5% DMSO+95% Saline: 2.9 mg/mL (5 mM), In vivo: Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
DMSO: 42.86 mg/mL (73.89 mM)
Ethanol: 5.8 mg/mL (10 mM)
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
10 mM0.1724 mL0.8621 mL1.7242 mL8.6210 mL
DMSO
1mg5mg10mg50mg
20 mM0.0862 mL0.4310 mL0.8621 mL4.3105 mL
50 mM0.0345 mL0.1724 mL0.3448 mL1.7242 mL

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