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Fenofibric acid

Catalog No. T1402 CAS 42017-89-0

Synonyms: Trilipix, FNF acid, NSC 281318

Fenofibric acid (FNF acid) is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.

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Fenofibric acid, CAS 42017-89-0

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1 g	In stock	$ 33.00
1 mL * 10 mM (in DMSO)	In stock	$ 30.00

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Purity: 99.94%

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Description	Fenofibric acid (FNF acid) is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.
Targets&IC50	COX-2:48 nM, PPARγ:1.47 µM(EC50), PPARα:22.4 µM(EC50), PPARδ:1.06 µM(EC50)
In vitro	Fibric acids, active forms of fibrate drugs and activators of peroxisome proliferator-activated receptor-alpha (PPARα), are also known for an HDL-raising effect. Fibric acids enhance fatty acid catabolism and accordingly reduce plasma lipid level, predominantly triglyceride (TG). Fenofibric acid increases the expression of ABCA1 and apoA-I–mediated HDL production. The effect on ABCA1 expression was through the enhancement of the transcription of the ABCA1 gene being dependent on LXR[1].
In vivo	Fenofibric acid attenuates aberrant increases of circulating EPC(Endothelial Progenitor Cells) in OIR mice. Inhibitory effect of Fenofibric acid on EPC mobilization in the OIR model is PPARα-dependent.Fenofibric acid Inhibits hypoxia-induced retinal EPC increase in a PPARα-dependent manner. Fenofibric acid decreases CXCR4-positive EPC in the circulation, downregulates the serum SDF-1 level and suppresses HIF-1a and SDF-1 overexpression in the retina[1].
Cell Research	PPAR activators fenofibric acid is dissolved in DMSO and added to the culture medium containing 0.2% BSA. RAW264 cells are washed with PBS and cultured an additional 48 hours in the presence of fenofibric acid in DMEM/F-12(1:1) medium containing 2% TCM and 0.2% BSA. During the last 24 hours of the drug treatment, 300 mol/L of dibutyryl cAMP and apoA-I (10 μg/mL) are added to the medium. THP-1 cells are also treated with the compound and apoA-I in 0.2% BSA-RPMI 1640 medium and 0.1% BSA-MEM. Cholesterol and choline-phospholipid released into the medium by apoA-I are determined enzymatically. Adherent cells are dissolved in 0.1 N NaOH for protein determination by bicinchoninic acid protein assay system. (Only for Reference)

Synonyms	Trilipix, FNF acid, NSC 281318
Molecular Weight	318.75
Formula	C17H15ClO4
CAS No.	42017-89-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 32 mg/mL (100.39 mM)

References and Literature

1. Arakawa R, et al. Arterioscler Thromb Vasc Biol. 2005, 25(6):1193-1197. 2. Wang Z, et al. Invest Ophthalmol Vis Sci. 2014, 55(6):3820-3832.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Drug Repurposing Compound Library Bioactive Lipid Compound Library Orally Active Compound Library Transcription Factor-Targeted Compound Library Neuronal Signaling Compound Library Anti-COVID-19 Compound Library Mitochondria-Targeted Compound Library Protease Inhibitor Library

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Keywords

Fenofibric acid 42017-89-0 DNA Damage/DNA Repair Immunology/Inflammation Metabolism Neuroscience Proteases/Proteasome COX MMP PPAR Peroxisome proliferator-activated receptors Inhibitor inhibit NSC-281318 Cyclooxygenase Trilipix FNF acid NSC 281318 NSC281318 inhibitor

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