Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fezolinetant (ESN-364) is an antagonist of the neurokinin 3 receptor (NK3R). It is used for the treatment of menopausal hot flushes.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 97.00 | |
2 mg | In stock | $ 153.00 | |
5 mg | In stock | $ 320.00 | |
10 mg | In stock | $ 466.00 | |
25 mg | In stock | $ 747.00 | |
50 mg | In stock | $ 1,070.00 | |
100 mg | In stock | $ 1,450.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 285.00 |
Description | Fezolinetant (ESN-364) is an antagonist of the neurokinin 3 receptor (NK3R). It is used for the treatment of menopausal hot flushes. |
In vivo | ESN364 inhibits the pulse pattern of LH in all treated animals. ESN364 (10, 25, 50 mg/kg, orally) also block the LH surge and decreases ovarian hormone levels throughout the menstrual cycle in monkeys. ESN364 (5 mg/kg, p.o.) lowers plasma LH, but not FSH, in the castrated monkey. Fezolinetant (1 mg/kg, iv bolus) reversibly inhibits the regular, pulsatile secretion of LH in the ovariectomized ewe [1]. |
Synonyms | ESN-364 |
Molecular Weight | 358.39 |
Formula | C16H15FN6OS |
CAS No. | 1629229-37-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (27.9 mM), Sonification is recommended
You can also refer to dose conversion for different animals. More
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Fezolinetant 1629229-37-3 GPCR/G Protein Neuroscience Neurokinin receptor Inhibitor Neurokinin Receptor Tachykinin receptor ESN-364 inhibit ESN 364 NK receptor ESN364 inhibitor