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Ganetespib

Catalog No. T2309 CAS 888216-25-9

Synonyms: STA-9090

Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Ganetespib, CAS 888216-25-9

Pack Size	Availability	Price/USD
5 mg	In stock	$ 61.00
10 mg	In stock	$ 89.00
25 mg	In stock	$ 135.00
50 mg	In stock	$ 169.00
100 mg	In stock	$ 263.00
200 mg	In stock	$ 446.00
500 mg	In stock	$ 739.00
1 mL * 10 mM (in DMSO)	In stock	$ 68.00

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Purity: 99.95%

Purity: 99.27%

Purity: 98.8%

Purity: 98%

Purity: 97.29%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.
Targets&IC50	HSP90:4 nM
Kinase Assay	Exponentially growing cells are processed in lysis buffer (20 mM HEPES, pH 7.4, 1 mM EDTA, 5 mM MgCl2, 100 mM KCl) and incubated with increasing concentrations of 17-AAG or ganetespib for 30 min at 4°C, and incubated with biotin-GM linked to Dynabeads MyOne Streptavidin T1 magnetic beads for 1 h at 4°C. Beads are washed three times in lysis buffer and heated for 5 min at 95°C in SDS-PAGE sample buffer. Samples are resolved on 4-12% Bis-Tris gradient gel and Western blots are performed using an anti-HSP90 antibody.
Cell Research	A total of 1.5 × 103 OSA cells are seeded in 96-well plates in 10% serum-containing complete medium and incubated overnight to determine the 50% inhibitory concentrations. Plates are, harvested at day 5 following 0.001, 0.005, 0.01, 0.05, 0.1, 0.5 and 1 μM Ganetespib, treatment and analyzed. Fluorescence measurements are made using a plate reader with excitation at 485 nm and emission detection at 530 nm. Relative cell number is calculated as a percentage of the control wells: absorbance of sample/absorbance of DMSO treated cells × 100.(Only for Reference)

Synonyms	STA-9090
Molecular Weight	364.4
Formula	C20H20N4O3
CAS No.	888216-25-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 38 mg/mL (104.3 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. McCleese Jk, et al. Int J Cancer. 2009, 125(12), 2792-2801. 2. Wang Y, et al. Curr Opin Investig Drugs. 2010 , 11(12), 1466-1476. 3. Ying W, et al. Mol Cancer Ther. 2012, 11(2), 475-484. 4. Lin TY, et al. Exp Hematol. 2008, 36(10), 1266-1277. 5. Peng Y C, Wang S, Zhang Y, et al. Hsp90β inhibitors prevent GLT-1 degradation but have no beneficial efficacy on absence epilepsy[J]. Journal of Asian natural products research. 2018 Nov 17:1-11.

Citations

1. Peng Y C, Wang S, Zhang Y, et al. Hsp90β inhibitors prevent GLT-1 degradation but have no beneficial efficacy on absence epilepsy. Journal of Asian Natural Products Research. 2018 Nov 17:1-11 2. Qiu C, Shen X, Lu H, et al.Combination therapy with HSP90 inhibitors and piperlongumine promotes ROS-mediated ER stress in colon cancer cells.Cell Death Discovery.2023, 9(1): 375. 3. Huang Z, Li S, Zhong L, et al.Effect of resveratrol on herpesvirus encephalitis: evidences for its mechanisms of action.Phytomedicine.2024: 155476.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Inhibitor Library Anti-Cancer Drug Library ReFRAME Related Library Bioactive Compound Library Exosome Compound Library Anti-Colorectal Cancer Compound Library Human Metabolite Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ganetespib 888216-25-9 Angiogenesis Apoptosis Chromatin/Epigenetic Cytoskeletal Signaling Metabolism HIF HSP Heat shock proteins inhibit Inhibitor STA 9090 STA9090 STA-9090 inhibitor

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